{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T07:05:27Z","timestamp":1771225527862,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T00:00:00Z","timestamp":1744588800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T00:00:00Z","timestamp":1744588800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Although considered the gold standard, pressure wire\u2010derived fractional flow reserve (PW\u2010FFR) and instantaneous wave\u2010free ratio (PW\u2010iFR) are not sufficiently adopted. Vessel fractional flow reserve (vFFR) is a potentially less invasive surrogate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To validate the diagnostic performance of vFFR against the wire\u2010based physiological assessments in real\u2010world clinical settings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this single\u2010center retrospective study, we analyzed 479 patients (586 vessels) who underwent PW\u2010FFR and vFFR in the same vessel, and evaluated the correlation between vFFR and PW\u2010FFR using PW\u2010FFR\u2009\u2266\u20090.80 as the reference. Additionally, we analyzed 378 patients (455 vessels) with vFFR, PW\u2010FFR, and PW\u2010iFR, and 93 patients (119 vessels) with vFFR, PW\u2010FFR, and resting full\u2010cycle ratio (RFR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The indications for coronary angiography were stable angina (92%), unstable angina (6.3%), and non\u2010ST\u2010elevation myocardial infarction (1.5%). The target vessels were the left anterior descending artery (61%), left circumflex artery (20%), and right coronary artery (19%). A good correlation was found between vFFR and PW\u2010FFR (\n                      <jats:italic>R<\/jats:italic>\n                      \u2009=\u20090.67;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) with a mean bias of 0.0068\u2009\u00b1\u20090.0786. vFFR demonstrated good accuracy at predicting PW\u2010FFR \u22660.80 (area under the curve [AUC] = 0.86; 95% confidence interval [CI]: 0.83\u20100.89). At a vFFR cut\u2010off value of \u22660.80, the sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic accuracy for predicting PW\u2010FFR \u22660.80 were 78.8%, 82.5%, 77.6%, 83.5%, and 80.9%, respectively, with a Cohen's Kappa coefficient of 0.612. Similar results were observed for vFFR with PW\u2010iFR and RFR.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>vFFR demonstrated good correlation and diagnostic performance compared with wire\u2010based physiological assessments.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.31534","type":"journal-article","created":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T06:00:12Z","timestamp":1744696812000},"page":"207-217","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Diagnostic Performance of Angiography\u2010Based Vessel\u2010Fractional Flow Reserve Compared with Various Wire\u2010Based Physiological Assessments"],"prefix":"10.1002","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-9635-6975","authenticated-orcid":false,"given":"Asahi","family":"Oshima","sequence":"first","affiliation":[{"name":"Division of Cardiology Mitsui Memorial Hospital Tokyo Japan"},{"name":"CORRIB Research Center for Advanced Imaging and Core lab School of Medicine, University of Galway Galway Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Ninomiya","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine Iwate Medical University Iwate Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Sekiguchi","sequence":"additional","affiliation":[{"name":"Division of Cardiology Mitsui Memorial Hospital Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daiki","family":"Yoshiura","sequence":"additional","affiliation":[{"name":"Division of Cardiology Mitsui Memorial Hospital Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Gonda","sequence":"additional","affiliation":[{"name":"Division of Cardiology Mitsui Memorial Hospital Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Horiuchi","sequence":"additional","affiliation":[{"name":"Division of Cardiology Mitsui Memorial Hospital Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanori","family":"Taniwaki","sequence":"additional","affiliation":[{"name":"Division of Cardiology Mitsui Memorial Hospital Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitomi","family":"Yuzawa","sequence":"additional","affiliation":[{"name":"Division of Cardiology Mitsui Memorial Hospital Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kota","family":"Komiyama","sequence":"additional","affiliation":[{"name":"Division of Cardiology Mitsui Memorial Hospital Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Division of Cardiology Mitsui Memorial Hospital Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshinobu","family":"Onuma","sequence":"additional","affiliation":[{"name":"CORRIB Research Center for Advanced Imaging and Core lab School of Medicine, University of Galway Galway Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9636-1104","authenticated-orcid":false,"given":"Patrick W.","family":"Serruys","sequence":"additional","affiliation":[{"name":"CORRIB Research Center for Advanced Imaging and Core lab School of Medicine, University of Galway Galway Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kengo","family":"Tanabe","sequence":"additional","affiliation":[{"name":"Division of Cardiology Mitsui Memorial Hospital Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2102-033X","authenticated-orcid":false,"given":"Masahiko","family":"Asami","sequence":"additional","affiliation":[{"name":"Division of Cardiology Mitsui Memorial Hospital Tokyo Japan"},{"name":"Department of Cardiovascular Medicine Gunma University Graduate School of Medicine Maebashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,4,14]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2021.09.006"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehae177"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-21-1041"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.037021"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2024.1468888"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12928-024-00988-5"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-21-00471"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2023.04.026"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.707454"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2023.01.062"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcha.2022.100986"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.25270\/jic\/21.00438"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.30511"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-19-00466"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2020.08.006"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2018.02.014"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.10.1102"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)02248-0"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)02175-5"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.11.003"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-18-00342"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-021-01855-4"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2024.12.017"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehad552"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehad582"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1915922"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.07.072"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2022.10.054"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.31534","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccd.31534","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.31534","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T06:09:16Z","timestamp":1771222156000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.31534"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,14]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1002\/ccd.31534"],"URL":"https:\/\/doi.org\/10.1002\/ccd.31534","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"value":"1522-1946","type":"print"},{"value":"1522-726X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,14]]},"assertion":[{"value":"2025-02-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}