{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T04:18:56Z","timestamp":1774585136006,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T00:00:00Z","timestamp":1745452800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T00:00:00Z","timestamp":1745452800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Murray law\u2010based Quantitative Flow Ratio (\u03bcQFR) is an innovative AI\u2010driven method for evaluating coronary lesions using contrast flow velocity estimates. Unlike traditional approaches, \u03bcQFR does not require pressure wires or hyperemia induction. However, its accuracy compared to Fractional Flow Reserve (FFR) for calcified lesions (ACC\/AHA classification B2 or C) remains underexplored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study aimed to evaluate the diagnostic accuracy of \u03bcQFR in detecting hemodynamically significant calcified coronary stenosis, defined as FFR\u2009\u2264\u20090.80.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this two\u2010center, investigator\u2010initiated trial, patients with calcified lesions (B2 or C, 30%\u201390% diameter stenosis) and FFR assessment during coronary angiography were included. \u03bcQFR was calculated by a nurse blinded to the FFR results. Sensitivity and specificity of \u03bcQFR were compared with FFR as the gold standard.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 125 patients, paired \u03bcQFR and FFR data were available for 107 patients and 120 lesions. Mean FFR, \u03bcQFR, and percent stenosis were 0.775 (95% CI: 0.757\u20130.793), 0.788 (95% CI: 0.772\u20130.805), and 56.75% (\u2009\u00b1\u200910.14%), respectively. \u03bcQFR demonstrated a sensitivity of 75% (95% CI: 65.6%\u201384.6%), a specificity of 77.8% (95% CI: 63.5%\u201392.0%), a diagnostic precision of 75.8% and an area under the receiver operating characteristic curve of 0.813 (95% CI: 0.714\u20130.911). The positive predictive value was 88.7%, and the negative predictive value was 57.1%. The positive and negative likelihood ratios were 3.38 and 0.32, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\u03bcQFR is simple to compute and offers moderate diagnostic accuracy for calcified coronary stenosis. It provides a valuable alternative when FFR is unavailable or technically challenging.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.31553","type":"journal-article","created":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:03:31Z","timestamp":1745463811000},"page":"377-383","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Diagnostic Accuracy of Angiography\u2010Derived Murray Law\u2010Based Quantitative Flow Ratio (\u03bcQFR) Versus Pressure\u2010Derived Fractional Flow Reserve (FFR) in Moderate to Severe Calcified Coronary Lesions\u2014The DIAMOND Study"],"prefix":"10.1002","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-2650-3009","authenticated-orcid":false,"given":"Wesley","family":"Bennar","sequence":"first","affiliation":[{"name":"Department of Cardiology University and Hospital Fribourg Villars\u2010sur\u2010Gl\u00e2ne 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