{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T04:10:50Z","timestamp":1791432650132,"version":"4.3.3"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T00:00:00Z","timestamp":1745452800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T00:00:00Z","timestamp":1745452800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Intravascular lithotripsy (IVL) has emerged as a novel therapeutic modality for the management of calcified coronary lesions. The effectiveness and safety of IVL specifically in the context of left main disease remains uncertain and limited. We performed a meta\u2010analysis to consolidate existing data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Online databases Medline, Embase, Cochrane were searched for studies using IVL during percutaneous coronary intervention (PCI) of calcified left main disease. The outcomes of interest were procedural success, procedural complications and cardiovascular (CV) events. Pooled proportions with 95% confidence intervals (CI) were calculated using a random\u2010effects model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 10 studies with 435 patients (mean age 73.1 years, 73.1% males) were included. The pooled outcomes were procedural success 98.8% (95% CI 95.58\u2212100), perforation 0.02% (95% CI 0.00\u22120.87), major dissection 0.87% (95% CI 0.00\u22123.97), slow\u2010flow\/no\u2010reflow 0.27% (95% CI 0.00\u22121.47) and abrupt vessel closure 0.01% (95% CI 0.00\u22121.01). In\u2010hospital CV events were major adverse CV events (MACE) 2.14% (95% CI 0.64\u22124.21), death 0.96% (95% CI 0.00\u22122.98), CV death 0.46% (95% CI 0.00\u22122.17), myocardial infarction (MI) 0.94% (95% CI 0.04\u22122.56), stent thrombosis 0.99% (95% CI 0.00\u22126.14) and target vessel revascularization 0% (95% CI 0.00\u22120.32). Thirty\u2010day outcomes were MACE 4.79% (95% CI 1.51\u22129.35), mortality 3.09% (95% CI 0.00\u22129.69) and MI 2.25% (95% CI 0.45\u22124.95).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Use of IVL during PCI of calcified left main disease is associated with a favorable procedural rates of success, with low risk of procedural complications and ischemic events.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.31554","type":"journal-article","created":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:22:08Z","timestamp":1745464928000},"page":"336-348","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Safety and Efficacy of Intravascular Lithotripsy in Calcified Left Main Coronary Artery Disease: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9560-8390","authenticated-orcid":false,"given":"Shanmukh Sai Pavan","family":"Lingamsetty","sequence":"first","affiliation":[{"name":"Internal Medicine Mamata Medical College Khammam India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harshith","family":"Thyagaturu","sequence":"additional","affiliation":[{"name":"Department of Cardiology West Virginia University Heart and Vascular Institute Morgantown West Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5660-782X","authenticated-orcid":false,"given":"Sahib","family":"Singh","sequence":"additional","affiliation":[{"name":"Internal Medicine Sinai Hospital Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avinashsingh","family":"Eswarsingh","sequence":"additional","affiliation":[{"name":"Department of cardiology East Carolina University Greenville North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shwetha","family":"Gopal","sequence":"additional","affiliation":[{"name":"Department of Cardiology Bassett Medical Center  New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dipesh","family":"Ludhwani","sequence":"additional","affiliation":[{"name":"University of Maryland Shore Regional Health Easton Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0760-2085","authenticated-orcid":false,"given":"Ademola","family":"Ajibade","sequence":"additional","affiliation":[{"name":"Department of Medicine West Virginia University Morgantown West Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-0246-2119","authenticated-orcid":false,"given":"Vijaykumar","family":"Sekar","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Lehigh Valley Health Network  Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikrant","family":"Jagadeesan","sequence":"additional","affiliation":[{"name":"Department of Cardiology West Virginia University Heart and Vascular Institute Morgantown West Virginia 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