{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T07:04:58Z","timestamp":1771225498984,"version":"3.50.1"},"reference-count":46,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T00:00:00Z","timestamp":1745798400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T00:00:00Z","timestamp":1745798400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Contemporary data have demonstrated that a complete revascularization (CR) strategy reduces adverse cardiovascular events compared with culprit vessel only\u2010Percutaneous Coronary Intervention (CO\u2010PCI) in ST Elevation Myocardial Infarction (STEMI). The optimal strategy of CR versus CO\u2010PCI in Non\u2010ST\u2010Elevation Acute Coronary Syndrome (NSTE\u2010ACS) remains unclear and was the goal of this meta\u2010analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic search of PubMed, Embase, and Cochrane databases for English\u2010language studies from inception till November 2024 comparing CR versus CO\u2010PCI in NSTE\u2010ACS patients with multi\u2010vessel disease was performed. A meta\u2010analysis was performed using a random\u2010effects model to calculate the risk ratio (RR) and 95% confidence interval (CI). Primary outcomes were all\u2010cause mortality and myocardial reinfarction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Eleven studies with total 36,997 NSTE\u2010ACS patients were included in study with mean follow up of 31.3 months. CR showed reduction in all\u2010cause mortality (1,457 of 16,939) compared to CO\u2010PCI (2126 of 16,939) (RR: 0.66; 95% CI: 0.55 to 0.79). Myocardial reinfarction occurred in 149 of 6404 in CR versus 248 of 6404 in CO\u2010PCI group (RR:0.57; 95% CI: 0.43 to 0.76). Composite endpoint was noted in 299 of 2,129 patients from CR vs 418 of 2131 patients from CO\u2010 PCI (RR:0.72; 95% CI: 0.63 to 0.82). Repeat revascularization was noted in 504 of 5661 patients from CR versus 849 of 5663 in CO\u2010 PCI patients group (RR:0.60; 95% CI: 0.54 to 0.66).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In NSTEMI and multivessel disease, CR reduces all\u2010cause mortality, recurrent myocardial infarction, composite outcome, and repeat revascularization compared to CO\u2010PCI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.31558","type":"journal-article","created":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T08:25:14Z","timestamp":1745828714000},"page":"454-463","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Complete Revascularization (CR) Versus Culprit\u2010Only Percutaneous Coronary Intervention (CO\u2010PCI) in NSTE\u2010ACS with Multivessel Disease: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3726-4889","authenticated-orcid":false,"given":"Kesar","family":"Prajapati","sequence":"first","affiliation":[{"name":"Internal Medicine, Metropolitan Hospital Center, NYC Health\u2009+\u2009Hospital New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9560-8390","authenticated-orcid":false,"given":"Shanmukh Sai Pavan","family":"Lingamsetty","sequence":"additional","affiliation":[{"name":"Mamata Medical College Khammam India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harshith","family":"Thyagaturu","sequence":"additional","affiliation":[{"name":"Department of Cardiology West Virginia University Heart and Vascular Institute Morgantown West Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phillip","family":"Englund","sequence":"additional","affiliation":[{"name":"West Virginia School of Medicine Morgantown West Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-0246-2119","authenticated-orcid":false,"given":"Vijaykumar","family":"Sekar","sequence":"additional","affiliation":[{"name":"Department of Medicine Lehigh Valley Health Network Allentown Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dipesh","family":"Ludhwani","sequence":"additional","affiliation":[{"name":"Department of Cardiology University of Maryland Shore Regional Health  Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vikrant","family":"Jagadeesan","sequence":"additional","affiliation":[{"name":"Department of Cardiology West Virginia University Heart and Vascular Institute Morgantown West Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,4,28]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.111.970699"},{"issue":"4","key":"e_1_2_11_3_1","article-title":"Complete Versus Culprit\u2010Only Revascularization for ST\u2010Segment\u2010Elevation Myocardial Infarction and Multivessel Disease: A Meta\u2010Analysis and Trial Sequential Analysis of Randomized Trials","volume":"8","author":"Bangalore S.","year":"2015","journal-title":"Circulation: Cardiovascular Interventions [Internet]"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcha.2021.100813"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1907775"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d5928"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i4919"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cct.2006.04.004"},{"key":"e_1_2_11_10_1","doi-asserted-by":"crossref","unstructured":"M.Harrer P.Cuijpers T. 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