{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T07:04:55Z","timestamp":1771225495147,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T00:00:00Z","timestamp":1745798400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T00:00:00Z","timestamp":1745798400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The management of patients with chronic total occlusion (CTO) poses a persistent challenge, necessitating a tailored treatment strategy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study aimed to investigate the intricate interplay between treatment selection, ischemia burden reduction, and symptom relief in patients with isolated CTO lesions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The Prospective Evaluation of Treatment Strategies in patients presenting with Chronic Total Occlusion (PETS\u2010CTO) registry is a prospective, non\u2010randomized study that evaluated patients at enrollment and follow\u2010up using the Seattle Angina questionnaire (SAQ) and stress ischemia tests. Patients were allocated into three treatment arms: optimal medical therapy (OMT), percutaneous coronary intervention (C TO\u2010PCI), or coronary artery bypass grafting (CABG). Changes in the angina symptoms and ischemic burden were the primary endpoints, while a clinical composite of death, myocardial infarction, and angina\u2010related rehospitalization was considered as the secondary outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 157 patients, 45% were in the CTO\u2010PCI group, 45% in the OMT group, and 10% underwent CABG. CTO\u2010PCI group demonstrated favorable changes in summary SAQ score (12.3%, 95% CI: 3.4%\u221221.5%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.008) compared to OMT. CTO\u2010PCI patients more frequently shifted from an ischemic to a nonischemic stress test at follow\u2010up compared to OMT (60% vs. 5.6%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). No correlation was observed between angina scores and proven ischemia at baseline and follow\u2010up assessments.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Effective management of CTO requires comprehensive evaluation, and although angina relief and ischemic burden are individually influential, our findings reveal a lack of correlation between these factors, emphasizing the complexity in guiding treatment decisions (PETS\u2010CTO; NCT04145167).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.31559","type":"journal-article","created":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T02:18:26Z","timestamp":1745893106000},"page":"443-453","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Prospective Evaluation of Treatment Strategies in Patients Presenting With Chronic Total Occlusion: The PETS\u2010CTO Registry"],"prefix":"10.1002","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3605-505X","authenticated-orcid":false,"given":"Enrico","family":"Poletti","sequence":"first","affiliation":[{"name":"Hartcentrum Ziekenhuis aan de Stroom (ZAS) Middelheim Antwerp Belgium"},{"name":"Department of Cardiology, Vrije Universiteit Brussel (VUB) Universitair Ziekenhuis Brussel (UZ Brussel) Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9825-6589","authenticated-orcid":false,"given":"Carlo","family":"Zivelonghi","sequence":"additional","affiliation":[{"name":"Hartcentrum Ziekenhuis aan de Stroom (ZAS) Middelheim Antwerp Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5625-3176","authenticated-orcid":false,"given":"Gianluca","family":"Castaldi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine University Hospitals Leuven Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Vermeersch","sequence":"additional","affiliation":[{"name":"Hartcentrum Ziekenhuis aan de Stroom (ZAS) Middelheim Antwerp Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carl","family":"Convens","sequence":"additional","affiliation":[{"name":"Hartcentrum Ziekenhuis aan de Stroom (ZAS) Middelheim Antwerp Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Selleslagh","sequence":"additional","affiliation":[{"name":"Hartcentrum Ziekenhuis aan de Stroom (ZAS) Middelheim Antwerp Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edgard","family":"Prihadi","sequence":"additional","affiliation":[{"name":"Hartcentrum Ziekenhuis aan de Stroom (ZAS) Middelheim Antwerp 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