{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T07:04:22Z","timestamp":1771225462582,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Sex differences in congenital heart disease are known to effect outcomes, however, there is limited data on its role in atrial septal defect (ASD) closure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>We aimed to investigate sex differences in baseline characteristics, procedural and long\u2010term outcomes of patients who underwent transcatheter ASD closure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This single\u2010center, retrospective cohort study enrolled adult patients undergoing ASD closure between 2005 and 2016 at the Toronto General Hospital, Canada. Information on index procedure and follow\u2010up was extracted from the hospital medical records.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the 853 patients included, 281 (32.9%) were male and 572 (67.1%) were female. Females more frequently presented with dyspnea or palpitations, whereas males had more cardiovascular comorbidities. More males presented with right ventricular (RV) dysfunction than females. Females had higher RV systolic pressures and a higher prevalence of moderate\u2010to\u2010severe tricuspid regurgitation (TR). Procedure\u2010related complications were rare and not different by sex. At 12\u2010month follow\u2010up, both males and females showed comparable decreases in RV diameter, RV systolic pressure, and TR severity. After a mean follow\u2010up of 3 years (SD\u2009=\u20095), no significant differences were observed in the incidence of death (adjusted hazard ratio (HR)\u2009=\u20091.48 [95% CI 0.38\u22125.74];\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.57), need for cardioversion or ablation, cerebrovascular events, and pacemaker implantation. Females had a lower hazard of new\u2010onset atrial fibrillation than males (HR\u2009=\u20090.63 [95% CI 0.41\u22121.00];\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Although patient profiles differed by sex, procedural and long\u2010term outcomes were comparable, suggesting that females and males benefit equally from transcatheter ASD closure.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.31561","type":"journal-article","created":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T08:29:10Z","timestamp":1746174550000},"page":"472-480","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sex\u2010Specific Outcomes in Patients Undergoing Transcatheter Closure of Atrial Septal Defects: Do They Benefit Equally?"],"prefix":"10.1002","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2731-2667","authenticated-orcid":false,"given":"Lore","family":"Schrutka","sequence":"first","affiliation":[{"name":"Toronto Congenital Cardiac Centre for Adults, Peter Munk Cardiac Centre University Health Network Toronto Ontario Canada"},{"name":"Department of Internal Medicine II, Division of Cardiology Medical University of Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lusine","family":"Abrahamyan","sequence":"additional","affiliation":[{"name":"Toronto General Hospital Research Institute University Health Network (UHN) Toronto Ontario Canada"},{"name":"Institute of Health Policy, Management and Evaluation University of Toronto Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0913-9087","authenticated-orcid":false,"given":"Varnita","family":"Vishwanath","sequence":"additional","affiliation":[{"name":"Arizona College of Osteopathic Medicine Midwestern University Glendale Arizona USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6428-241X","authenticated-orcid":false,"given":"Eduardo","family":"Flores\u2010Umanzor","sequence":"additional","affiliation":[{"name":"Toronto Congenital Cardiac Centre for Adults, Peter Munk Cardiac Centre University Health Network Toronto Ontario Canada"},{"name":"Cardiology Department, Cardiovascular Institute Hospital Cl\u00ednic, University of Barcelona Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1545-709X","authenticated-orcid":false,"given":"Areeba","family":"Asghar","sequence":"additional","affiliation":[{"name":"Toronto General Hospital Research Institute University Health Network (UHN) Toronto Ontario Canada"},{"name":"Institute of Health Policy, Management and Evaluation University of Toronto Toronto Ontario Canada"},{"name":"Schulich School of Medicine University of Western Ontario London Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1407-1825","authenticated-orcid":false,"given":"Lee","family":"Benson","sequence":"additional","affiliation":[{"name":"The Labatt Family Heart Centre The Hospital for Sick Children, University of Toronto Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark D.","family":"Osten","sequence":"additional","affiliation":[{"name":"Toronto Congenital Cardiac Centre for Adults, Peter Munk Cardiac Centre University Health Network Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric M.","family":"Horlick","sequence":"additional","affiliation":[{"name":"Toronto Congenital Cardiac Centre for Adults, Peter Munk Cardiac Centre University Health Network Toronto Ontario 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