{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T18:58:10Z","timestamp":1780513090416,"version":"3.54.1"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T00:00:00Z","timestamp":1747612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T00:00:00Z","timestamp":1747612800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Paclitaxel\u2010(PCB) and sirolimus\u2010coated balloons (SCB) are used for treatment of in\u2010stent restenosis (ISR) and de novo (DN) lesions. Studies comparing major adverse cardiac events (MACE) after PCB versus SCB are limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study aims to contribute to this knowledge gap and enhance the understanding of optimal strategies for treating ISR and DN lesions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>EASTBOURNE and PEARL are large\u2010scale, prospective clinical registries, evaluating the performance of drug\u2010coated balloons. PEARL included patients who underwent percutaneous coronary intervention using Protege PCB and EASTBOURNE included patients treated with MagicTouch SCB in study centers in Europe and Asia. We combined these registries and used logistic regression analysis to assess the association between SCB\/PCB and the likelihood of experiencing MACE, a composite of all\u2010cause mortality, myocardial infarction (MI) and target\u2010lesion revascularisation (TLR) at 1\u2010year follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Out of 2596 patients, MACE was observed more frequently in ISR lesions (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20091292 patients, SCB:17.8% vs. PCB:14.1%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.12) versus DN lesions (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20091304 patients, SCB:6.4% vs. PCB:6.1%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20091.00). The adjusted hazards ratio (HR) for MACE was 1.17 (95% CI: 0.59\u20131.23,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.40). As regards DN lesions, no significant difference was found in MACE (SCB: 6.4% vs. PCB 6.1%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20091.00). The adjusted HR for MACE was 1.24 (95% CI: 0.20\u20132.01,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.13). There were no differences in the individual components of the primary endpoint.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This real\u2010world comparison demonstrated comparable outcomes between new\u2010generation PCB and SCB in terms of MACE at 1\u2010year follow\u2010up, across different lesion settings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.31587","type":"journal-article","created":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T03:04:56Z","timestamp":1747623896000},"page":"625-632","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Comparison of Sirolimus\u2014Versus Paclitaxel\u2010Coated Balloons in Coronary Artery Disease: One\u2010Year Results of Two Real\u2010World Prospective Registries"],"prefix":"10.1002","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4051-2994","authenticated-orcid":false,"given":"Selina","family":"Vlieger","sequence":"first","affiliation":[{"name":"Department of Cardiology Albert Schweitzer Hospital Dordrecht the Netherlands"},{"name":"Department of Cardiology ErasmusMC Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin M.","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Cardiology Albert Schweitzer Hospital Dordrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7539-5463","authenticated-orcid":false,"given":"Filippo Luca","family":"Gurgoglione","sequence":"additional","affiliation":[{"name":"Division of Cardiology Parma University Hospital Parma Italy"},{"name":"DCB Academy Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tay M.","family":"Heang","sequence":"additional","affiliation":[{"name":"Pantai Hospital Ayer Keroh Melaka Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander J. J.","family":"Ijsselmuiden","sequence":"additional","affiliation":[{"name":"Department of Cardiology Maastricht University Medical centre Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5982-1669","authenticated-orcid":false,"given":"Alfonso","family":"Ielasi","sequence":"additional","affiliation":[{"name":"IRCCS Ospedale Galeazzi Sant'Ambrogio Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Boersma","sequence":"additional","affiliation":[{"name":"Department of Cardiology ErasmusMC Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee C.","family":"Yan","sequence":"additional","affiliation":[{"name":"Sultanah Aminah Johor Bahru Johor Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7964-4479","authenticated-orcid":false,"given":"Alessandro","family":"Sciahbasi","sequence":"additional","affiliation":[{"name":"Sandro Pertini Hospital Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramesh","family":"Singh","sequence":"additional","affiliation":[{"name":"University Malaya Medical Centre Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Karavolias","sequence":"additional","affiliation":[{"name":"Metropolitan Hospital Pireas Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dario","family":"Gattuso","sequence":"additional","affiliation":[{"name":"Fondazione Ricerca e Innovazione Cardiovascolare Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohit M.","family":"Oemrawsingh","sequence":"additional","affiliation":[{"name":"Department of Cardiology Albert Schweitzer Hospital Dordrecht the Netherlands"},{"name":"Amphia Hospital Breda the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5808-7810","authenticated-orcid":false,"given":"Bernardo","family":"Cortese","sequence":"additional","affiliation":[{"name":"DCB Academy Milan Italy"},{"name":"Fondazione Ricerca e Innovazione Cardiovascolare Milan Italy"},{"name":"University Hospitals Cleveland Medical Center, Harrington Heart &amp; Vascular Institute Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.2459\/JCM.0000000000000806"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.294.7.819"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2007.11.021"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carrev.2021.04.013"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2023.05.005"},{"key":"e_1_2_10_7_1","first-page":"S1553","article-title":"Angiographic and Clinical Impact of Balloon Inflation Time in Percutaneous Coronary Interventions With Sirolimus\u2010Coated Balloon: A Subanalysis of the Eastbourne Study","volume":"24","author":"Gurgoglione F. L.","year":"2024","journal-title":"Cardiovascular Revascularization Medicine: Including Molecular Interventions"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.011245"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2019.09.028"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2020.09.005"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2018.11.040"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-23-00868"},{"key":"e_1_2_10_13_1","article-title":"Sirolimus\u2010 vs Paclitaxel\u2010Coated Balloon for the Treatment of Coronary In\u2010Stent Restenosis: The SIBLINT\u2010ISR Randomized Trial","volume":"24","author":"Liu H.","year":"2025","journal-title":"JACC. Cardiovascular Interventions"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.31154"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2022.01.012"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.122.012305"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2023.09.026"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2016.08.006"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.30851"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/futurepharmacol4040041"},{"key":"e_1_2_10_21_1","first-page":"266","article-title":"Drug\u2010Coated Balloons on the \u2018Big Stage\u2019: Is This Technology Ready for An All\u2010Comer Population With De Novo Lesions?","volume":"6","author":"Wanha W.","year":"2024","journal-title":"REC Interventional Cardiology"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.25270\/jic\/21.00339"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.31587","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccd.31587","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.31587","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T06:08:57Z","timestamp":1771222137000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.31587"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,19]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1002\/ccd.31587"],"URL":"https:\/\/doi.org\/10.1002\/ccd.31587","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"value":"1522-1946","type":"print"},{"value":"1522-726X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,19]]},"assertion":[{"value":"2025-03-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}