{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T15:02:58Z","timestamp":1788966178075,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:00:00Z","timestamp":1748304000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:00:00Z","timestamp":1748304000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Intravascular lithotripsy (IVL) is an innovative treatment for coronary artery calcification (CAC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study aimed to compare procedural and clinical outcomes of intracoronary imaging (ICI)\u2010guided percutaneous coronary intervention (PCI) versus angiography\u2010guided PCI with IVL in patients with CAC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 509 patients were analyzed from the BENELUX\u2010IVL registry (May 2019 to September 2024). Angiography\u2010guided PCI with IVL was defined as therapy under solely fluoroscopic guidance. ICI\u2010guided PCI with IVL was defined as PCI with IVL and concomitant use of ICI for procedural guidance either pre\u2010 and\/or post\u2010IVL. The primary endpoint was procedural success, defined as Thrombolysis In Myocardial Infarction (TIMI) 3 flow, residual stenosis &lt;\u200930%, and absence of in\u2010hospital major adverse cardiovascular events (MACE). Safety endpoints included procedural complications and MACE up to 2\u2010year follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 537 lesions were treated with IVL: 252 (46.9%) angiography\u2010guided and 285 (53.1%) ICI\u2010guided. The ICI\u2010guided group had more complex lesions, with higher rates of aorto\u2010ostial (20.2% vs. 30.9%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005), chronic total occlusions (2.8% vs. 12.3%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001), and long\u2010segment lesions (58.7% vs. 69.5%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.009). Procedural success rates were comparable between groups (88.7% vs. 89.7%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.71), as were device success (97.9% vs. 97.4%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.72) and technical success (89.1% vs. 91.5%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.35). MACE rates remained similar at all time points up to 2\u2010year follow\u2010up (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Procedural success was comparable between angiography\u2010guided and ICI\u2010guided PCI with IVL, despite greater lesion complexity in the ICI\u2010guided group. Complication rates were similar, with no significant differences in MACE or mortality at long\u2010term follow\u2010up.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.31637","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T06:50:02Z","timestamp":1748328602000},"page":"869-878","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Comparison of Procedural and Clinical Outcomes of Angiography\u2010 Versus Imaging\u2010Guided Percutaneous Coronary Intervention With Intravascular Lithotripsy"],"prefix":"10.1002","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-3321-3803","authenticated-orcid":false,"given":"Akshay A. S.","family":"Phagu","sequence":"first","affiliation":[{"name":"Department of Cardiology Leiden University Medical Center Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0860-6969","authenticated-orcid":false,"given":"Martijn J. H.","family":"van Oort","sequence":"additional","affiliation":[{"name":"Department of Cardiology Leiden University Medical Center Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Oliveri","sequence":"additional","affiliation":[{"name":"Department of Cardiology Leiden University Medical Center Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4986-8623","authenticated-orcid":false,"given":"Brian O.","family":"Bingen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Leiden University Medical Center Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6555-4019","authenticated-orcid":false,"given":"Gianluca","family":"Mincione","sequence":"additional","affiliation":[{"name":"Department of Cardiology Maasstad Ziekenhuis Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Paradies","sequence":"additional","affiliation":[{"name":"Department of Cardiology Maasstad Ziekenhuis Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1703-7921","authenticated-orcid":false,"given":"Bimmer E. 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M.","family":"Claessen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Amsterdam University Medical Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aukelien C.","family":"Dimitriu\u2010Leen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Radboud University Medical Center Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tessel N.","family":"Vossenberg","sequence":"additional","affiliation":[{"name":"Department of Cardiology Medisch Centrum Leeuwarden Leeuwarden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joelle","family":"Kefer","sequence":"additional","affiliation":[{"name":"Department of Cardiology Cliniques Universitaires Saint\u2010Luc Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hany","family":"Girgis","sequence":"additional","affiliation":[{"name":"Department of Cardiology Jeroen Bosch Ziekenhuis \u2018s\u2010Hertogenbosch The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"van der Kley","sequence":"additional","affiliation":[{"name":"Department of Cardiology Leiden University Medical Center Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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