{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T07:03:42Z","timestamp":1771225422511,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T00:00:00Z","timestamp":1748822400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T00:00:00Z","timestamp":1748822400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Little is known about stroke volume index (SVi) change and its prognostic implication in patients with low\u2010flow aortic stenosis (AS) undergoing aortic valve replacement (AVR) and conflicting results are present in literature. The aim of this study was to evaluate the postoperative change in SVi and its impact on outcomes in patients with low\u2010flow severe AS undergoing AVR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Retrospective observational study of a high\u2010volume tertiary care center including consecutive patients with low\u2010flow (SVi\u2009\u2264\u200935\u2009mL\/m\n                      <jats:sup>2<\/jats:sup>\n                      ) severe AS who underwent AVR (either surgical or transcatheter) with available comprehensive pre\u2010 and post\u2010AVR echocardiographic assessment. Post\u2010AVR SVi improvement was defined as an increase\u2009\u2265\u200915% from baseline, while SVi normalization was defined as post\u2010AVR SVi\u2009&gt;\u200935\u2009mL\/m\n                      <jats:sup>2<\/jats:sup>\n                      . A up to 36\u2010month follow\u2010up was conducted and the study primary endpoint was the composite of all cause\u2010mortality and hospitalizations for heart failure.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      One\u2010hundred\u2010fifty\u2010one patients (mean age 80\u2009\u00b1\u20098 years, 53.6% female) were included. After AVR, SVi improved by &gt; 15% in 51 (33.8%) and normalized in 51 (33.8%) patients. At a median follow\u2010up of 17 (7\u221232) months, 62 (52.6%) patients reached the primary composite endpoint. SVi improvement, but not SVi normalization, was associated with better survival free from the primary endpoint (log rank\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02 and 0.056, respectively). Multivariate analysis confirmed that both SVi improvement and its absolute change per mL\/m\n                      <jats:sup>2<\/jats:sup>\n                      unit carried a better prognosis (adj. HR 0.51 [0.28\u20130.91,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02] and 0.97 (0.94\u20130.99),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.016, respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In patients with low\u2010flow AS undergoing AVR, early post\u2010procedural SVi increase has beneficial prognostic significance. These findings highlight the importance of post\u2010AVR hemodynamic assessment and may help refine risk stratification in this vulnerable population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.31654","type":"journal-article","created":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T01:20:52Z","timestamp":1748913652000},"page":"1012-1022","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Early Stroke Volume Variation After Transcatheter or Surgical Aortic Valve Replacement Predicts Clinical Outcomes in Low\u2010Flow Aortic Stenosis"],"prefix":"10.1002","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5726-8396","authenticated-orcid":false,"given":"Giorgio","family":"Fiore","sequence":"first","affiliation":[{"name":"Unit of Cardiovascular Imaging, IRCCS Ospedale San Raffaele Milan 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