{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T07:03:44Z","timestamp":1771225424982,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T00:00:00Z","timestamp":1748995200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T00:00:00Z","timestamp":1748995200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The optimal management of patients on oral anticoagulant therapy (OAT) undergoing percutaneous coronary intervention (PCI) remains debated. There are three possible strategies: performing the procedure on OAT, bridging OAT with heparins or stopping OAT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this sub\u2010analysis of the PERSEO multicenter registry, we selected a cohort of patients on OAT undergoing PCI and we appraised in\u2010hospital outcomes according to three different peri\u2010procedural strategies: uninterrupted OAT, interrupted OAT, and interrupted OAT with bridging therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The study population consisted of 763 patients, of whom 76% were receiving direct oral anticoagulants (DOACs) whereas the remaining were on vitamin K antagonists (VKAs). OAT was interrupted in 70%, bridged in 24% and continued in 6% of patients, the latter mainly undergoing emergent procedures. The overall rates of major adverse cardiac and cerebrovascular events and bleedings were 1.7% and 6.8%, respectively. The overall rate of thromboembolic events was very low (0.1%), even in patients who interrupted OAT (0.2%). Bridging strategy (OR 2.39, 95% CI 1.12\u22125.09), increasing age (OR 1.07, 95% CI 1.02\u22121.12) and white blood cell count (OR 1.17, 95% CI 1.07\u22121.27) were independently associated with bleedings, whereas radial approach was a protective factor (OR 0.36, 95% CI 0.17\u22120.77). Continued anticoagulation (bridging therapy or OAT) was also an independent predictor of bleedings (OR 2.22, 95% CI 1.21\u22124.08).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this study, OAT interruption was a safe strategy for both bleedings and thromboembolic events, whereas continued anticoagulation, especially bridging, was associated with increased bleeding rate. Radial approach should be preferred in this clinical setting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>\n                      The PERSEO study was registered on\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/ClinicalTrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      with the ID NCT03392948 (last update 2022\u201007\u201022).\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.31657","type":"journal-article","created":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T00:48:47Z","timestamp":1749084527000},"page":"1177-1186","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Peri\u2010Procedural Management of Oral Anticoagulant Therapy in Patients Undergoing Percutaneous Coronary Intervention: Insights from the PERSEO Multicenter Registry"],"prefix":"10.1002","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5116-2737","authenticated-orcid":false,"given":"Stefano","family":"Rigattieri","sequence":"first","affiliation":[{"name":"Cardiology Unit Sant'Andrea University Hospital Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ernesto","family":"Cristiano","sequence":"additional","affiliation":[{"name":"Humanitas Gavazzeni clinic Bergamo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvatore","family":"De Rosa","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences Magna Graecia University Catanzaro Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Calabr\u00f2","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Sciences University of Campania \u201cLuigi Vanvitelli\u201d Caserta Italy"},{"name":"Division of Cardiology A.O.R.N. \u201cSant'Anna e San Sebastiano\u201d Caserta Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni Paolo","family":"Talarico","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Policlinico Casilino Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5808-7810","authenticated-orcid":false,"given":"Bernardo","family":"Cortese","sequence":"additional","affiliation":[{"name":"Harrington Heart and Vascular Institute University Hospitals Cleveland Ohio USA"},{"name":"Fondazione Ricerca e Innovazione Cardiovascolare Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Caruso","sequence":"additional","affiliation":[{"name":"Division of Interventional Cardiology ARNAS Civico Hospital Palermo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Redivo","sequence":"additional","affiliation":[{"name":"Cardiology Unit Sant'Andrea University Hospital Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5159-3200","authenticated-orcid":false,"given":"Giuseppe","family":"Musumeci","sequence":"additional","affiliation":[{"name":"S.C. 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