{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T07:03:30Z","timestamp":1771225410379,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T00:00:00Z","timestamp":1749081600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T00:00:00Z","timestamp":1749081600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Myocardial infarction (MI) is a major global cause of morbidity and mortality. Reperfusion therapy in acute MI reduces mortality, but microvascular obstruction (MVO) may persist. Tirofiban improves myocardial perfusion by inhibiting platelet aggregation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study aims to compare intracoronary tirofiban delivery via guiding catheter versus aspiration catheter on MVO and myocardial salvage in ST\u2010segment elevation MI (STEMI) patients undergoing PCI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this randomized study, 118 STEMI patients were classified into two groups: Group A (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200956) received tirofiban via guiding catheter, and Group B (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200962) via aspiration catheter. Cardiac MRI assessed MVO%, myocardial salvage index, and left ventricular function. Major adverse cardiovascular events (MACE) were monitored for 6 months.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Patients receiving tirofiban via aspiration catheter had a significantly lower median MVO (0.8% vs. 2.5%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and a higher myocardial salvage index (56.1% \u00b1 8.1% vs. 44.8% \u00b1 5.9%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) compared to the other group. No significant difference was reported between both groups regarding MACE (10.7 vs. 4.8,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.305). Minor bleeding occurred at similar rates in both groups (10.7% vs. 9.7%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.852). Multivariate linear regression analysis confirmed that tirofiban administration via aspiration catheter was a significant predictor of reduced MVO% (\n                      <jats:italic>B<\/jats:italic>\n                      \u2009=\u2009\u22121.303,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and increased myocardial salvage index (\n                      <jats:italic>B<\/jats:italic>\n                      \u2009=\u20094.669, 95%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Intracoronary tirofiban delivery via aspiration catheter significantly reduces MVO and improves myocardial salvage in STEMI patients undergoing PCI compared to the guiding catheter method, without increasing the risk of bleeding or MACE.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.31665","type":"journal-article","created":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T01:23:52Z","timestamp":1749173032000},"page":"1187-1195","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effect of Intracoronary Tirofiban Through Guiding Catheter Compared With Intracoronary Tirofiban Through Aspiration Catheter on the Microvascular Obstruction in Patients With STEMI Undergoing PCI: A Cardiac MR Study"],"prefix":"10.1002","volume":"106","author":[{"given":"Ahmed Mohamed Shawky","family":"Asfour","sequence":"first","affiliation":[{"name":"Cardiology Department, Faculty of Medicine Cairo University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5713-1326","authenticated-orcid":false,"given":"Mohamed Osman","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Critical Care Medicine Department, Faculty of Medicine Cairo University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karim Salem","family":"Mashhour","sequence":"additional","affiliation":[{"name":"Critical Care Medicine Department, Faculty of Medicine Cairo University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0472-4308","authenticated-orcid":false,"given":"Ashraf Ahmed Abdel","family":"Megeed","sequence":"additional","affiliation":[{"name":"Cardiology Department National Heart Institute Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8533-6694","authenticated-orcid":false,"given":"Akram Mohamed Abd","family":"El\u2010Bary","sequence":"additional","affiliation":[{"name":"Critical Care Medicine Department, Faculty of Medicine Cairo University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1532-429X-15-5"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2011.09.014"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03337726"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20140470"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1532-429X-14-68"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.109.897439"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.11110228"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000010850"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000127867.41621.85"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi459"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/09537104.2021.1881953"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/9609970"},{"issue":"2","key":"e_1_2_9_14_1","first-page":"76","article-title":"Clinical Outcome of Intracoronary Versus Intravenous High\u2010Dose Bolus Administration of Tirofiban in Diabetic Patients Undergoing Primary Percutaneous Coronary Intervention","volume":"16","author":"Ghonim A. A.","year":"2019","journal-title":"South African Journal of Diabetes and Vascular Disease"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.01.204"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e15842"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCA.0000000000000825"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000008223"},{"issue":"3","key":"e_1_2_9_19_1","doi-asserted-by":"crossref","first-page":"85","DOI":"10.4103\/1995-705X.102145","article-title":"High Bolus Tirofiban vs Abciximab in Acute STEMI Patients Undergoing Primary PCI\u2014The Tamip Study","volume":"13","author":"Balghith M.","year":"2012","journal-title":"Heart Views: The Official Journal of the Gulf Heart Association"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2012.02.041"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.31665","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccd.31665","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.31665","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T06:04:45Z","timestamp":1771221885000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.31665"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,5]]},"references-count":19,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10.1002\/ccd.31665"],"URL":"https:\/\/doi.org\/10.1002\/ccd.31665","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"value":"1522-1946","type":"print"},{"value":"1522-726X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,5]]},"assertion":[{"value":"2025-03-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}