{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T22:44:30Z","timestamp":1784241870234,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,6,8]],"date-time":"2025-06-08T00:00:00Z","timestamp":1749340800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,6,8]],"date-time":"2025-06-08T00:00:00Z","timestamp":1749340800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Radial artery spasm (RAS) is the most common complication of transradial cardiac catheterization (TRA), potentially leading to procedural failure, crossover to an alternative access site, and increased patient discomfort. Preventing RAS is critical for procedural success and safety.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To evaluate whether pre\u2010procedural administration of oral verapamil reduces the incidence of clinical and ultrasound\u2010defined radial artery spasm in patients undergoing TRA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a prospective, randomized clinical trial (NCT06447688) comparing 120\u2009mg of oral verapamil with placebo administered 2\u2009h before the procedure. The primary endpoints were the incidence of clinical RAS and ultrasound\u2010based radial artery area change. Secondary endpoints included procedural success, contrast volume, dose area product, and fluoroscopy time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 231 screened patients, 150 were randomized (75 verapamil, 75 placebo). The verapamil group showed significantly lower rates of clinical RAS (4% vs. 30.7%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and ultrasonographically defined RAS (10.7% vs. 48%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). In addition, reductions in proximal and middle radial artery area were significantly smaller in the verapamil group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001 for both). No significant differences were observed in procedural success, fluoroscopy time, radiation dose, or contrast volume.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Oral verapamil administered 2\u2009h before TRA significantly reduces the rate of radial artery spasm and vasoconstriction. This strategy may improve patient comfort and procedural outcomes without increasing adverse effects.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.31675","type":"journal-article","created":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T01:54:39Z","timestamp":1749434079000},"page":"1247-1254","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Role of Oral Verapamil in Preventing Radial Spasm During Transradial Angiography"],"prefix":"10.1002","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-4628-6672","authenticated-orcid":false,"given":"Sefa","family":"Sural","sequence":"first","affiliation":[{"name":"Department of Cardiology, Faculty of Medicine Istinye University Sariyer Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5414-2771","authenticated-orcid":false,"given":"Mehmet Erc\u00fcment","family":"D\u00f6\u011fen","sequence":"additional","affiliation":[{"name":"Department of Radiology, Faculty of Medicine Istinye University Sariyer Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0675-0377","authenticated-orcid":false,"given":"Baris","family":"Duzel","sequence":"additional","affiliation":[{"name":"Department of Cardiology Mersin City Training and Research Hospital Mersin Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2896-6934","authenticated-orcid":false,"given":"Ozkan","family":"Karaca","sequence":"additional","affiliation":[{"name":"Department of Cardiology Mersin City Training and Research Hospital Mersin Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9416-9701","authenticated-orcid":false,"given":"Emmanouil S.","family":"Brilakis","sequence":"additional","affiliation":[{"name":"Minneapolis Heart Institute and Minneapolis Heart Institute Foundation Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4775-1402","authenticated-orcid":false,"given":"Sevket","family":"Gorgulu","sequence":"additional","affiliation":[{"name":"Cardiology Department Biruni University School of Medicine Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics14171897"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5273(98)00074-6"},{"key":"e_1_2_9_4_1","article-title":"Transradial Versus Transfemoral Approach for Diagnostic Coronary Angiography and Percutaneous Coronary Intervention in People With Coronary Artery Disease","volume":"4","author":"Kolkailah A. A.","year":"2018","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hlc.2022.05.039"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.25163"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.5603\/CJ.a2017.0125"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1681.2002.03705.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0304(199806)44:2<147::AID-CCD5>3.0.CO;2-6"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/joic.12514"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.21639"},{"issue":"7","key":"e_1_2_9_12_1","first-page":"843","article-title":"Incidence and Predictors of Radial Artery Spasm During Transradial Coronary Angiography and Intervention","volume":"123","author":"Jia D. A.","year":"2010","journal-title":"Chinese Medical Journal"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aen103"},{"issue":"7","key":"e_1_2_9_14_1","first-page":"843","article-title":"Incidence and Predictors of Radial Artery Spasm During Transradial Coronary Angiography and Intervention","volume":"123","author":"Jia D. A.","year":"2010","journal-title":"Chinese Medical Journal"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1536\/jhj.45.723"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/clc.23906"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2022.09.032"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carrev.2015.08.008"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/joic.12000"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0377-1237(17)30686-X"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1532\/HSF98.20051002"},{"issue":"3","key":"e_1_2_9_22_1","article-title":"Topical Nitroglycerine Reduces Radial Access Site Failure\u2014TNTRASP Study","volume":"142","author":"Gopalakrishnan P. P.","year":"2020","journal-title":"Circulation"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/0267659117727823"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2013.03.048"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcha.2020.100689"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-197815030-00001"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.31675","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccd.31675","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.31675","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T06:03:30Z","timestamp":1771221810000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.31675"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,8]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10.1002\/ccd.31675"],"URL":"https:\/\/doi.org\/10.1002\/ccd.31675","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"value":"1522-1946","type":"print"},{"value":"1522-726X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,8]]},"assertion":[{"value":"2025-01-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}