{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T07:02:39Z","timestamp":1771225359303,"version":"3.50.1"},"reference-count":44,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T00:00:00Z","timestamp":1750032000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T00:00:00Z","timestamp":1750032000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The prognostic impact of complete revascularization in patients with non\u2010ST\u2010segment elevation myocardial infarction (NSTEMI) and multivessel disease (MVD) remains uncertain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study aimed to compare clinical outcomes between complete and incomplete revascularization in NSTEMI patients with MVD, assessing the optimal timing and strategy for revascularization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed 2460 consecutive NSTEMI patients with MVD enrolled across five institutions between January 2021 and December 2022. The primary endpoint was major adverse cardiac and cerebrovascular events (MACCEs: all\u2010cause death, recurrent myocardial infarction, heart failure, stroke, and urgent revascularization) and major adverse cardiac events (MACEs: cardiovascular death, recurrent myocardial infarction, heart failure, and urgent revascularization). Multivariable Cox proportional hazards regression analysis was conducted to adjust for important clinical characteristics, and adjusted hazard ratio (aHR) with a 95% confidence interval (CI) was calculated to assess the risk of clinical outcomes. Inverse probability weighting analysis was performed to verify the robustness of the results.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Over a median 528\u2010day follow\u2010up, complete revascularization was associated with a significantly lower risk of MACCEs (aHR 0.48, 95% CI 0.36\u20130.64) and MACEs (aHR 0.45, 95% CI 0.33\u20130.60) compared to incomplete revascularization. Single\u2010stage and multistage complete revascularization showed comparable outcomes (MACCEs: aHR 0.93, 95% CI 0.47\u20131.85; MACEs: aHR 0.89, 95% CI 0.44\u20131.82). However, compared to delayed multistage complete revascularization, early multistage complete revascularization significantly reduced the risk of MACCEs (aHR 0.05, 95% CI 0.01\u20130.28) and MACEs (aHR 0.03, 95% CI 0.01\u20130.27). These results were consistent after confounder adjustment by inverse probability weighting analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Complete revascularization is an effective treatment strategy for reducing the risk of adverse clinical outcomes in NSTEMI patients with MVD. Moreover, an early multistage complete revascularization may be a better option.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.31679","type":"journal-article","created":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T07:40:38Z","timestamp":1750059638000},"page":"1342-1357","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Complete Revascularization Strategies on the Clinical Outcomes of Patients With Non\u2010ST\u2010Segment Elevation Myocardial Infarction and Multivessel Disease: Multicentre Real\u2010World Evidence From China"],"prefix":"10.1002","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6405-0862","authenticated-orcid":false,"given":"Chongyou","family":"Rao","sequence":"first","affiliation":[{"name":"Department of Critical Care Medicine The First Medical Center of the Chinese PLA General Hospital Beijing China"},{"name":"Medical Big Data Research Center Medical Innovation Research Division of the Chinese PLA General Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qin","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine The First Medical Center of the Chinese PLA General Hospital Beijing China"},{"name":"Medical Big Data Research Center Medical Innovation Research Division of the Chinese PLA General Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zongren","family":"Li","sequence":"additional","affiliation":[{"name":"Medical Big Data Research Center Medical Innovation Research Division of the Chinese PLA General Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liqiang","family":"Fu","sequence":"additional","affiliation":[{"name":"Medical Big Data Research Center Medical Innovation Research Division of the Chinese PLA General Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology Xuzhou Central Hospital Xuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Cardiology Affiliated Hospital of Chengde Medical University Chengde China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jixian","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Cardiology Cangzhou People's Hospital Cangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Information Yuncheng Central Hospital Yuncheng China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunlun","family":"He","sequence":"additional","affiliation":[{"name":"Medical Big Data Research Center Medical Innovation Research Division of the Chinese PLA General Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6154-013X","authenticated-orcid":false,"given":"Feihu","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine The First Medical Center of the Chinese PLA General Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6,16]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2004.03.051"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehm184"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.15095"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.07.089"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehad191"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2023.07.043"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.4244\/eijy14m08_05"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2007.09.007"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.27331"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2314149"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0148756"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2021.02.021"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2300468"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2015.10.034"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/circinterventions.123.013737"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/jaha.120.016575"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2020.04.034"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.120.046754"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/cir.0000000000000617"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.106.685313"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2021.07.022"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv029"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-020-00457-5"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2407791"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0229491"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehae151"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.37616\/2212-5043.1377"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1161\/circinterventions.118.007305"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jeae289"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n1593"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032292"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.28.10.2508"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(16)31276-4"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(23)00351-3"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.10.082"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1161\/circinterventions.112.974485"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1161\/jaha.116.005381"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10554-016-0943-8"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/joic.12390"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.1033475"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.4070\/kcj.2015.0358"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.2147\/clep.S167138"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.23004"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2020.02.043"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.31679","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccd.31679","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.31679","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T06:03:36Z","timestamp":1771221816000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.31679"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,16]]},"references-count":44,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10.1002\/ccd.31679"],"URL":"https:\/\/doi.org\/10.1002\/ccd.31679","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"value":"1522-1946","type":"print"},{"value":"1522-726X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,16]]},"assertion":[{"value":"2025-04-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}