{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T07:02:17Z","timestamp":1771225337711,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,6,15]],"date-time":"2025-06-15T00:00:00Z","timestamp":1749945600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,6,15]],"date-time":"2025-06-15T00:00:00Z","timestamp":1749945600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Backgrounds<\/jats:title>\n                    <jats:p>Significant mitral regurgitation (MR) is common worldwide, yet surgical correction rates remain low due to high\u2010risk patient profiles. Transseptal mitral valve replacement (TSMVR) has emerged as a minimally invasive alternative, but its feasibility in Asian populations remains underexplored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study assessed the short\u2010term feasibility of the HighLife TSMVR system for treating symptomatic MR in China.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective study included seven centers in China, integrating data from multicenter and localized cohorts with identical inclusion criteria. Patients with symptomatic MR (\u2265\u20093+) and high surgical risk were included, excluding those with unsuitable anatomy for the HighLife system. Preprocedural imaging was centrally adjudicated, and 30\u2010day outcomes were analyzed using R software (version 4.4.0).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty\u2010two patients (median age 70.5 years; 45.5% male) underwent the procedure. The predicted median mortality risk was 6.39%, with secondary MR in 81.8% of cases. Technical success was 95.5% (21\/22). Median durations of valve delivery, ring closure, transseptal puncture, and looping were 4.00, 8.50, 22.25, and 42.75\u2009min, respectively and 22.73% cases of tele\u2010proctoring. One patient required conversion to transcatheter aortic valve replacement, and two deaths occurred within 30 days. Significant improvements were observed in New York Heart Association class (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.033) and MR severity (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The HighLife TSMVR system demonstrated safety and efficacy in treating symptomatic MR in high\u2010risk Chinese patients, supporting its potential clinical applicability.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.31685","type":"journal-article","created":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T02:23:16Z","timestamp":1750040596000},"page":"1315-1323","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Short\u2010Term Feasibility of Transseptal Mitral Valve Replacement in China"],"prefix":"10.1002","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5004-2511","authenticated-orcid":false,"given":"Yi","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Cardiology, West China Hospital Sichuan University Chengdu China"},{"name":"Laboratory of Cardiac Structure and Function, Institute of Cardiovascular Diseases, West China Hospital Sichuan University Chengdu Sichuan China"},{"name":"Cardiac Structure and Function Research Key Laboratory of Sichuan Province, West China Hospital Sichuan University Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, West China Hospital Sichuan University Chengdu China"},{"name":"Laboratory of Cardiac Structure and Function, Institute of Cardiovascular Diseases, West China Hospital Sichuan University Chengdu Sichuan 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Hospital Sichuan University Chengdu China"},{"name":"Laboratory of Cardiac Structure and Function, Institute of Cardiovascular Diseases, West China Hospital Sichuan University Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Cardiology, West China Hospital Sichuan University Chengdu China"},{"name":"Laboratory of Cardiac Structure and Function, Institute of Cardiovascular Diseases, West China Hospital Sichuan University Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Cardiology, West China Hospital Sichuan University Chengdu China"},{"name":"Laboratory of Cardiac Structure and Function, Institute of Cardiovascular Diseases, West China Hospital Sichuan University Chengdu Sichuan 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