{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T08:26:26Z","timestamp":1773303986507,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T00:00:00Z","timestamp":1750032000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T00:00:00Z","timestamp":1750032000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Sirolimus\u2010coated balloon (SCB) is a potential treatment option for peripheral arterial disease (PAD). However, evidence is limited on the durability of the treatment effect in the longer term.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The aim of our study was to assess the long\u2010term efficacy and safety of SELUTION SCB in the treatment of the femoropopliteal steno\u2010occlusive disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a single\u2010center, all\u2010comers, observational registry in which 80 consecutive patients undergoing SELUTION SCB\u2010angioplasty due to femoropopliteal steno\u2010occlusive lesions were enrolled from February 2021 to March 2022. Assessments through 3 years included: primary patency (primary efficacy outcome), defined as freedom from restenosis determined by a duplex ultrasound peak systolic velocity ratio (PSVR)\u2009\u2264\u20092.4; freedom from clinically\u2010driven target lesion revascularization (CD\u2010TLR) and secondary patency, defined as freedom from new restenosis following the CD\u2010TLR (secondary efficacy outcomes); freedom from major adverse limb events (MALEs, primary composite safety outcome); change in median ankle\u2010brachial index (ABI) and Rutherford classification (functional outcomes).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>At 3 years, primary patency was 74.7% and freedom from CD\u2010TLR was 85.3%. The rate of CD\u2010TLR was 14.7% (11 patients). Among them, one patient experienced a new restenosis (failure of CD\u2010TLR), therefore secondary patency was 90.9%. Freedom from MALEs was 94.7%. Median ABI increased significantly from 0.4\u2009\u00b1\u20090.2 at baseline to 0.7\u2009\u00b1\u20090.3 at 36 months postprocedure, as well as Rutherford classification data improved.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These 3\u2010year findings suggest long\u2010term efficacy and safety of SELUTION SCB in the setting of femoropopliteal steno\u2010occlusive endovascular treatment. Larger cohorts and randomized controlled trials will be needed to confirm these results.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.31696","type":"journal-article","created":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T05:28:17Z","timestamp":1750051697000},"page":"1335-1341","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Long\u2010Term Efficacy and Safety of Sirolimus\u2010Coated Balloon in Femoropopliteal Steno\u2010Occlusive Disease: 3\u2010Year Outcomes"],"prefix":"10.1002","volume":"106","author":[{"given":"Michele","family":"Franzese","sequence":"first","affiliation":[{"name":"Catheterization Laboratory Montevergine Clinic Mercogliano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Ciliberti","sequence":"additional","affiliation":[{"name":"Catheterization Laboratory Montevergine Clinic Mercogliano Italy"},{"name":"Department of Advanced 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