{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T23:06:57Z","timestamp":1788390417531,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T00:00:00Z","timestamp":1750982400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T00:00:00Z","timestamp":1750982400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Coronary calcified nodules (CNs) are a challenging subset of calcific lesions associated with adverse procedural outcomes. While rotational atherectomy (RA) and balloon angioplasty (BA) have been traditionally used, orbital atherectomy (OA) offers a unique mechanism of plaque modification that may be advantageous in the treatment of CNs. Data on OA in CNs remains limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate procedural success, periprocedural safety, in\u2010hospital and long\u2010term outcomes of retrograde OA in the treatment of CNs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective analysis of all patients who underwent OA for angiographically identified coronary calcification between January 1, 2022 and March 31, 2024. A total of 312 patient underwent OA during this period, of whom 57 had a CN identified. Baseline demographics, lesion characteristics, procedural details, and outcomes were assessed. CNs were defined by angiographic or intravascular ultrasound appearance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The mean age was 71, 71.9% were male, 71.9% had diabetes, 40.3% had CKD and 15.8% had prior coronary artery bypass. The majority of lesions involved the left anterior descending artery (49.1%). Retrograde treatment using a 1.25\u2009mm burr at 80,000\u2009rpms was exclusively used. Angiographic success was achieved in 100% of cases. No perforations or flow\u2010limiting dissections were observed. During an average follow\u2010up of 325.57\u2009\u00b1\u2009233.45 days, there were no cases of early or late stent thrombosis, with one case of very late stent thrombosis. Major adverse cardiac events (MACE) occurred in 5.26% (three patients), comprising myocardial infarction in 3.51% (two patients) and target vessel revascularization in 1.75% (one patient).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this real\u2010world, single\u2010center, retrospective analysis, OA was safe and effective in treating coronary CNs, achieving high angiographic success with minimal periprocedural complications. These findings support the use of OA as a viable strategy for CNs, though further studies are warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.31724","type":"journal-article","created":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T05:44:54Z","timestamp":1751003094000},"page":"1584-1590","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Outcomes Following Orbital Atherectomy for Coronary Calcified Nodules: A Retrospective Single\u2010Center Experience"],"prefix":"10.1002","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-7630-3046","authenticated-orcid":false,"given":"Hassan","family":"Saleh","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Cardiology, School of Medicine University of Louisville Louisville Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8966-4189","authenticated-orcid":false,"given":"Divyansh","family":"Sharma","sequence":"additional","affiliation":[{"name":"Division of Cardiology Kirk Kerkorian School of Medicine at UNLV Las Vegas Nevada USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hesham","family":"Afify","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology, School of Medicine University of Louisville Louisville Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9339-5245","authenticated-orcid":false,"given":"Ravi","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology, School of Medicine University of Louisville Louisville Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sohail","family":"Ikram","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology, School of Medicine University of Louisville Louisville Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naresh","family":"Solankhi","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology, School of Medicine University of Louisville Louisville Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2015.02.003"},{"key":"e_1_2_8_3_1","doi-asserted-by":"crossref","unstructured":"T.Tada K.Miura A.Ikuta et al. Prevalence Predictors and Outcomes of In\u2010Stent Restenosis with Calcified Nodules.https:\/\/doi.org\/10.4244\/EIJ-D-21-00504.","DOI":"10.4244\/EIJ-D-21-00504"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2017.05.013"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2017.01.022"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.120.008686"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2011.07.014"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2024.03.032"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2023.03.009"},{"key":"e_1_2_8_10_1","doi-asserted-by":"crossref","unstructured":"C. V.Bourantas Y. J.Zhang S.Garg et al. Prognostic Implications of Coronary Calcification in Patients with Obstructive Coronary Artery Disease Treated by Percutaneous Coronary Intervention: A Patient\u2010Level Pooled Analysis of 7 Contemporary Stent Trials 2014 https:\/\/doi.org\/10.1136\/heartjnl-2013-305180.","DOI":"10.1136\/heartjnl-2013-305180"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.12.150"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(24)02891-2"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-44610-9"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.30118"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jscai.2023.101259"},{"key":"e_1_2_8_16_1","doi-asserted-by":"crossref","unstructured":"S.Khattak H.Sharma andS. Q.Khan. 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