{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T06:10:23Z","timestamp":1778998223262,"version":"3.51.4"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T00:00:00Z","timestamp":1751241600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T00:00:00Z","timestamp":1751241600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Transcatheter aortic valve replacement (TAVR) is a first\u2010line treatment for severe symptomatic aortic stenosis (AS) patients, and the preferred approach for TAVR is transfemoral. The double\u2010ProGlide preclose technique offers an effective and safe method for closure of transfemoral access site after TAVR. However, the debate is still ongoing whether a single\u2010ProGlide strategy is equal or even superior to a double one in terms of hemostasis and vascular complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The aim of this study is to examine the safety and efficacy of a single\u2010 versus double\u2010ProGlide strategy for vascular closure during transfemoral TAVR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with severe AS who underwent transfemoral TAVR in the second affiliated hospital Zhejiang university school of medicine in the period from June 2021 to December 2023 were included and divided by the number of ProGlide device. The primary outcome of this study was a composite of in\u2010hospital main access route related vascular complications, main access route related bleeding, and vascular closure device failure in accordance with Valve Academic Research Consortium\u20103 (VARC\u20103) criteria. The propensity\u2010score matched (PSM) analysis was used to account for differences in baseline characteristics, and binary logistic regression was used to determine the predictive factors for the primary outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 347 patients were included, of which 154 (44.0%) had a single ProGlide device used for arteriotomy closure, and 193 (56.0%) had a double one. After PSM, the incidence of primary composite outcome was significantly lower in the single\u2010ProGlide group (7.7% vs. 17.9%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.023), while the incidence of in\u2010hospital vascular complications (6.0% vs. 11.1%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.210) and bleeding (1.7% vs. 6.8%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.109) related to the main access route was lower but not significant. Multivariate logistic regression showed that single\u2010ProGlide (for double\u2010ProGlide, OR\u2009=\u20090.408, 95% CI\u2009=\u20090.182\u22120.914,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.029) and an increase in the minimal lumen diameter of main access route (per 1.0\u2009mm, OR\u2009=\u20090.618, 95% CI\u2009=\u20090.416\u22120.919,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.017) were protective factors for the primary outcome.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A single\u2010ProGlide device is a safe and effective mean of vascular closure after transfemoral TAVR and may have important clinical benefits compared to the commonly used double\u2010ProGlide technique.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.31725","type":"journal-article","created":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T02:54:59Z","timestamp":1751338499000},"page":"1639-1649","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparative Study of Single\u2010 Versus Double\u2010ProGlide Device Strategy for Access Site Closure of Transfemoral Transcatheter Aortic Valve Replacement"],"prefix":"10.1002","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-4355-0586","authenticated-orcid":false,"given":"Ranxi","family":"Li","sequence":"first","affiliation":[{"name":"Department of Cardiology The Second Affiliated Hospital, School of Medicine Zhejiang University Hangzhou China"},{"name":"State Key Laboratory of Transvascular Implantation Devices Hangzhou China"},{"name":"Heart Regeneration and Repair Key Laboratory of Zhejiang Province Hangzhou China"},{"name":"Transvascular Implantation Devices 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