{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:56:04Z","timestamp":1787500564889,"version":"build-2736575974"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,6,29]],"date-time":"2025-06-29T00:00:00Z","timestamp":1751155200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,6,29]],"date-time":"2025-06-29T00:00:00Z","timestamp":1751155200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Several studies have documented positive clinical outcomes associated with drug\u2010containing devices, such as drug\u2010eluting stents (DES) and drug\u2010coated balloons (DCB), for femoropopliteal artery (FPA) lesions. Endovascular therapy (EVT) using drug\u2010containing devices is the primary strategy, even for complex FP lesions. However, little is known about the clinical outcomes of the hybrid of DES and DCB therapies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To compare the efficacy of hybrid therapy with that of a full\u2010covered DES for FPA lesions in a real\u2010world setting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective multi\u2010center study enrolled 2105 consecutive patients (2173 de novo FPA lesions) who underwent EVT between 2018 and 2021. Among these, 99 FPA lesions treated with hybrid therapy and 369 FPA lesions treated with a full\u2010covered DES were analyzed. Propensity score matching was performed to compare clinical outcomes between hybrid and full\u2010covered DES groups, resulting in the analysis of 79 matched pairs. The primary outcome was patency at 1 year, with target lesion revascularization (TLR) also evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Primary patency and freedom from TLR at 1 year were comparable between the groups (hybrid vs. full\u2010covered DES: 79.6% vs. 88.3%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.23; and 86.9% vs. 93.6%, respectively;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.21). However, interaction analysis revealed that full\u2010covered DES provided significantly higher primary patency than hybrid therapy in FPA lesions without popliteal artery involvement (interaction\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.049).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Hybrid therapy achieved an acceptable clinical outcome for complex FPA lesions compared with full\u2010covered DES in a real\u2010world setting.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.31727","type":"journal-article","created":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T02:36:27Z","timestamp":1751250987000},"page":"1600-1609","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Drug\u2010Eluting Stent and Drug\u2010Coated Balloon Compared to Full\u2010Covered Drug\u2010Eluting Stent for Femoropopliteal Lesions: CENTAUR Study"],"prefix":"10.1002","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8563-6854","authenticated-orcid":false,"given":"Kenji","family":"Ogata","sequence":"first","affiliation":[{"name":"Department of Cardiology Miyazaki Medical Association Hospital Miyazaki Japan"},{"name":"Department of Cardiovascular Medicine, Graduate School of Medical Sciences Kumamoto University Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kensaku","family":"Nishihira","sequence":"additional","affiliation":[{"name":"Department of Cardiology Miyazaki Medical Association Hospital Miyazaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1402-062X","authenticated-orcid":false,"given":"Takahiro","family":"Tokuda","sequence":"additional","affiliation":[{"name":"Department of Cardiology Nagoya Heart Center Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3619-3794","authenticated-orcid":false,"given":"Naoki","family":"Yoshioka","sequence":"additional","affiliation":[{"name":"Department of Cardiology Ogaki Municipal Hospital Gifu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0238-1436","authenticated-orcid":false,"given":"Akiko","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Cardiology Sendai Kosei Hospital Miyagi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7764-2165","authenticated-orcid":false,"given":"Shunsuke","family":"Kojima","sequence":"additional","affiliation":[{"name":"Department of Cardiology Tokyo Bay Medical Center Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kohei","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Department of Cardiology Yokohama Eastern Hospital Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5179-1277","authenticated-orcid":false,"given":"Takashi","family":"Yanagiuchi","sequence":"additional","affiliation":[{"name":"Department of Cardiology Rakuwakai Otowa Hospital Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8733-473X","authenticated-orcid":false,"given":"Tatsuro","family":"Takei","sequence":"additional","affiliation":[{"name":"Department of Cardiology Tenyoukai Central Hospital Kagoshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9107-6438","authenticated-orcid":false,"given":"Tasuya","family":"Nakama","sequence":"additional","affiliation":[{"name":"Department of Cardiology Tokyo Bay Medical Center Chiba Japan"},{"name":"Department of Surgery, Division of Vascular Surgery The Jikei University School of 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