{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T10:32:33Z","timestamp":1785148353418,"version":"3.55.0"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Device\u2010related thrombosis (DRT) is a rare but serious complication following left atrial appendage occlusion (LAAO). A 58\u2010year\u2010old woman with permanent atrial fibrillation (AF), multiple comorbidities, and a history of transient ischemic attack despite anticoagulation underwent LAAO in December 2023. Initially prescribed oral anticoagulants, she discontinued them due to side effects and switched to single antiplatelet therapy. Nearly 1\u2010year postprocedure, a thrombus was detected on the LAAO device. Despite heparin infusion, she developed systemic embolism, resulting in splenic infarction and subsequent splenectomy. She was discharged on warfarin, but a persistent thrombus was noted on a 1\u2010month transesophageal echocardiogram, necessitating continued warfarin therapy and serial follow\u2010ups. The prediction, detection, and management of DRT remain challenging and uncertain due to a lack of robust evidence\u2010based protocols. Balancing bleeding and thrombotic risks, especially in frail patients, is complex. While LAAO is an effective stroke prevention strategy for AF patients, the risks of DRT should not be overlooked. Further research is essential to refine DRT management protocols.<\/jats:p>","DOI":"10.1002\/ccd.31736","type":"journal-article","created":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T01:40:15Z","timestamp":1751420415000},"page":"1652-1656","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Late\u2010Onset Device Related Thrombosis After Left Atrial Appendage Occlusion and Spleen Systemic Embolism: A Case Report"],"prefix":"10.1002","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-5696-8707","authenticated-orcid":false,"given":"Costanza Agata","family":"Bordonaro","sequence":"first","affiliation":[{"name":"Division of Cardiology, Azienda Ospedaliero\u2010Universitaria Policlinico \u201cRodolico\u2013San Marco\u201d University of Catania Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Capodanno","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Azienda Ospedaliero\u2010Universitaria Policlinico \u201cRodolico\u2013San Marco\u201d University of Catania Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,1]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehae176"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.1088782"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2023.10.046"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-21-01010"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.01.076"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2024.10.101"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2022.02.047"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2020.08.020"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2023.08.013"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab744"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2023.01.007"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJY19M08_01"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.10.021"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2022.07.014"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjco.2024.05.015"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjcr\/ytae438"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1530\/ERP-18-0083"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(94)90644-0"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1155\/cdr\/1849432"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-020-02205-5"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.117.005997"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.035090"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.31736","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccd.31736","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.31736","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T05:35:50Z","timestamp":1778996150000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.31736"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,1]]},"references-count":22,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1002\/ccd.31736"],"URL":"https:\/\/doi.org\/10.1002\/ccd.31736","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"value":"1522-1946","type":"print"},{"value":"1522-726X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,1]]},"assertion":[{"value":"2025-02-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}