{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T22:47:18Z","timestamp":1790203638137,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T00:00:00Z","timestamp":1751500800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T00:00:00Z","timestamp":1751500800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Data concerning the long\u2010term durability of transcatheter aortic valves (TAVs) in patients with bicuspid aortic stenosis (AS) are lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The study aims to report data on long\u2010term valve durability following transcatheter aortic valve replacement (TAVR) in bicuspid AS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This multicentre registry included patients who underwent TAVR for bicuspid AS with at least 2\u2010year echocardiographic follow\u2010up. The incidence of structural valve deterioration (SVD), bioprosthetic valve dysfunction (BVD), and bioprosthetic valve failure (BVF) was determined according to Valve Academic Research Consortium (VARC)\u20103 criteria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 894 patients (mean age: 75.6 years; 39% female), the median echocardiographic follow\u2010up was 48.7 months with a 5\u2010year cumulative incidence of moderate\u2010to\u2010severe SVD, severe SVD, severe BVD, and BVF of 8.1%, 3.2%, 11.4%, and 6.1%, respectively. Younger age (\u2264\u200975 years) was associated with a higher likelihood of reintervention (HR 2.40, log\u2010rank\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04). TAV downsizing was associated with higher rates of moderate\u2010to\u2010severe SVD (HR 3.05, log\u2010rank\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), severe BVD (HR 2.07, log\u2010rank\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003), and BVF (HR 3.25, log\u2010rank\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002). In the sub\u2010group with small annuli (area \u2264\u2009430\u2009mm\n                      <jats:sup>2<\/jats:sup>\n                      ), implantation of balloon\u2010expandable TAVs was associated with a higher rate of BVD in comparison with self\u2010expanding TAVs (HR: 3.27, log\u2010rank\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.008).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>TAVs demonstrated favorable 5\u2010year durability in patients with bicuspid AS, although younger patients were more likely to require valve reintervention. Nominal TAV sizing was associated with better durability outcomes as compared to TAV downsizing. Self\u2010expanding valves were associated with superior hemodynamics in patients with small annuli.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.31742","type":"journal-article","created":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T01:10:07Z","timestamp":1751591407000},"page":"1746-1757","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Long\u2010Term Durability of Transcatheter Aortic Valves in Patients With Bicuspid Aortic Stenosis"],"prefix":"10.1002","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9767-0603","authenticated-orcid":false,"given":"Yuheng","family":"Jia","sequence":"first","affiliation":[{"name":"The Heart Center Rigshospitalet Copenhagen Denmark"},{"name":"Department of Cardiology West China Hospital Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0118-5153","authenticated-orcid":false,"given":"Annette","family":"Maznyczka","sequence":"additional","affiliation":[{"name":"Leeds General Infirmary Leeds Teaching Hospitals NHS Trust Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8414-0726","authenticated-orcid":false,"given":"Mauro","family":"Boiago","sequence":"additional","affiliation":[{"name":"Clinique Pasteur Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4455-2865","authenticated-orcid":false,"given":"Arif","family":"Khokhar","sequence":"additional","affiliation":[{"name":"The Heart Center Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4488-1335","authenticated-orcid":false,"given":"Daijiro","family":"Tomii","sequence":"additional","affiliation":[{"name":"Cardiovascular Center Bern University Hospital, Inselspital University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3873-1652","authenticated-orcid":false,"given":"Antoinette","family":"Neylon","sequence":"additional","affiliation":[{"name":"Institut Cardiovasculaire Paris\u2010Sud Ho\u0302pital prive\u0301 Jacques Cartier, Ramsay\u2010Sante\u0301 Massy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline","family":"Danthine","sequence":"additional","affiliation":[{"name":"Institut Cardiovasculaire Paris\u2010Sud Ho\u0302pital prive\u0301 Jacques Cartier, Ramsay\u2010Sante\u0301 Massy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3318-0867","authenticated-orcid":false,"given":"Thomas","family":"Levesque","sequence":"additional","affiliation":[{"name":"Department of Cardiology Univ Rouen Normandie, Inserm U1096, CHU Rouen Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Bamford","sequence":"additional","affiliation":[{"name":"Leeds General Infirmary Leeds Teaching Hospitals NHS Trust Leeds UK"},{"name":"University of Newcastle Newcastle Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Toggweiler","sequence":"additional","affiliation":[{"name":"Heart Center Lucerne, Cardiology, Luzerner Kantonsspital Lucerne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5794-5676","authenticated-orcid":false,"given":"Federico","family":"Moccetti","sequence":"additional","affiliation":[{"name":"Heart Center Lucerne, Cardiology, Luzerner Kantonsspital Lucerne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jarkko","family":"Piuhola","sequence":"additional","affiliation":[{"name":"Research Unit of Biomedicine and Internal Medicine Medical Research Center Oulu University of Oulu Oulu Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3855-1815","authenticated-orcid":false,"given":"Marianna","family":"Adamo","sequence":"additional","affiliation":[{"name":"Cardiology Department ASST Spedali Civili di Brescia Brescia Italy"},{"name":"Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health University of Brescia Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0895-440X","authenticated-orcid":false,"given":"Mauro","family":"Massussi","sequence":"additional","affiliation":[{"name":"Cardiology Department ASST Spedali Civili di Brescia Brescia Italy"},{"name":"Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health University of Brescia Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5982-1669","authenticated-orcid":false,"given":"Alfonso","family":"Ielasi","sequence":"additional","affiliation":[{"name":"U.O. 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