{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T13:37:32Z","timestamp":1779111452940,"version":"3.51.4"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T00:00:00Z","timestamp":1753228800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T00:00:00Z","timestamp":1753228800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Initially, drug\u2010coated balloon (DCB) angioplasty was primarily employed for in\u2010stent restenosis (ISR) treatment. Over time, its indications have broadened to include de novo small\u2010vessel lesions and bifurcation lesions. However, there is a lack of effective strategies to reduce restenosis rates post\u2010DCB angioplasty.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Exploring the predictive value of quantitative flow ratio (QFR) and its derived angiographic microvascular resistance (AMR) for vascular restenosis following DCB angioplasty.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This study enrolled 108 patients who received DCB angioplasty during the period between February 2021 and October 2024. All patients underwent follow\u2010up coronary angiography at 1 year post\u2010procedure. Based on angiographic findings, patients were divided into a restenosis group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200938) and a non\u2010restenosis group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200970). The study compared preoperative parameters, surgical data, and postoperative variables.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The restenosis group demonstrated a significantly higher prevalence of diabetes (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05), greater history of smoking (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05), lower postoperative QFR values (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05), and a higher proportion of patients with AMR values exceeding 2.5 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05) compared to the non\u2010restenosis group. Multivariate logistic regression analysis identified postoperative QFR and high AMR values as independent predictors of restenosis after DCB therapy. ROC curve analysis demonstrated that the AUC for postoperative QFR in predicting restenosis was 0.727 (95% CI: 0.518\u20130.936,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05), which improved to 0.903 (95% CI: 0.782\u20131,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01) when combined with high AMR values.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Coronary angiography\u2010derived QFR and AMR are closely associated with vascular restenosis in patients treated with DCB. Routine postoperative measurement of QFR and AMR may enhance risk prediction for restenosis following DCB angioplasty.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.70028","type":"journal-article","created":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T08:49:48Z","timestamp":1753260588000},"page":"1951-1957","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The Predictive Value of Quantitative Flow Ratio and Its Derived Angiographic Microvascular Resistance for Restenosis Following Drug\u2010Coated Balloon Angioplasty"],"prefix":"10.1002","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-5206-1785","authenticated-orcid":false,"given":"Chenhang","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Internal Medicine Ningbo Medical Center Li Huili Hospital Ningbo China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2037-8356","authenticated-orcid":false,"given":"Li","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Internal Medicine Ningbo Medical Center Li Huili Hospital Ningbo China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyong","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Internal Medicine Ningbo Medical Center Li Huili Hospital Ningbo China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,23]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"Chinese Cardiovascular Disease Research Report in 2024[M]","author":"National Center for Cardiovascular Diseases","year":"2024"},{"issue":"06","key":"e_1_2_9_3_1","first-page":"105","article-title":"Development History, Research Status and Prospects of Percutaneous Coronary Intervention Approaches in China[J]","volume":"28","author":"Liu Y. 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