{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T07:07:10Z","timestamp":1787814430154,"version":"build-2784847793"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T00:00:00Z","timestamp":1753315200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T00:00:00Z","timestamp":1753315200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Drug\u2010coated balloons (DCBs) for femoropopliteal (FP) lesions have demonstrated superiority over standard percutaneous transluminal angioplasty (PTA) in maintaining vessel patency. However, data on whether the good durability of DCBs translates into improved wound outcome in chronic limb\u2010threatening ischemia (CLTI) patients are limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The aim of this study was to compare the effectiveness of FP\u2010DCBs with that of standard PTA in achieving superior wound healing outcomes in CLTI patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a sub\u2010analysis of the multicenter, retrospective, observational SAPLING (SAtellite database of Patients with chronic Limb\u2010threateniNG Ischemia) registry. CLTI patients with tissue loss who underwent endovascular therapy for FP lesions with either DCBs or PTA were analyzed using propensity score matching. Patients were classified into the DCB group or the PTA group. The primary outcome measure was 2\u2010year wound healing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 701 limbs were included in this study. After propensity score matching, the 2\u2010year cumulative incidence of wound healing was not significantly different between the DCB and PTA group (76.7% vs. 67.5%; hazard ratio: 1.129; 95% confidence interval: 0.861\u22121.480,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.382). Interaction analysis demonstrated that DCB use was associated with a higher wound healing rate in patients with Wound grade 2 or 3 (\n                      <jats:italic>p<\/jats:italic>\n                      for interaction\u2009=\u20090.002) and foot Infection grade 2 or 3 (\n                      <jats:italic>p<\/jats:italic>\n                      for interaction\u2009=\u20090.03) in the Wound, Ischemia, and foot Infection classification.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>DCB use for FP lesions was not significantly associated with superior wound healing in patients with CLTI. However, DCB may offer benefits for patients with higher wound and foot infection grades.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.70033","type":"journal-article","created":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T13:16:32Z","timestamp":1753362992000},"page":"1993-2004","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Impact of Femoropopliteal Drug\u2010Coated Balloon Use on Clinical Outcomes in Patients With Chronic Limb\u2010Threatening Ischemia"],"prefix":"10.1002","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-8665-2820","authenticated-orcid":false,"given":"Haruya","family":"Yamane","sequence":"first","affiliation":[{"name":"Cardiovascular Division NHO Osaka National Hospital Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosuke","family":"Hata","sequence":"additional","affiliation":[{"name":"Kansai Rosai Hospital Cardiovascular Center Amagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Iida","sequence":"additional","affiliation":[{"name":"Cardiovascular Division Osaka Police Hospital Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0514-106X","authenticated-orcid":false,"given":"Yasunori","family":"Ueda","sequence":"additional","affiliation":[{"name":"Cardiovascular Division NHO Osaka National Hospital Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuniyasu","family":"Ikeoka","sequence":"additional","affiliation":[{"name":"Cardiovascular Division NHO Osaka National Hospital Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1590-5227","authenticated-orcid":false,"given":"Taku","family":"Toyoshima","sequence":"additional","affiliation":[{"name":"Cardiovascular Division Osaka Police Hospital Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motoki","family":"Yasunaga","sequence":"additional","affiliation":[{"name":"Cardiovascular Division Osaka Police Hospital Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Nohara","sequence":"additional","affiliation":[{"name":"Division of Cardiology Osaka Rosai Hospital Sakai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akito","family":"Kawamura","sequence":"additional","affiliation":[{"name":"Division of Cardiology Osaka Rosai Hospital Sakai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sho","family":"Nakao","sequence":"additional","affiliation":[{"name":"Kansai Rosai Hospital Cardiovascular Center Amagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7564-2978","authenticated-orcid":false,"given":"Yohei","family":"Sotomi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Osaka University Graduate School of Medicine Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Sakata","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Osaka University Graduate School of Medicine Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,24]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.011245"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.119.044697"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.01.013"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2019.0325"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz698"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2005206"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-21-0171"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.122.025677"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2023.08.022"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/1526602817745565"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0706356"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.09.063"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.011004"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2013.05.022"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1406235"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx095"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.12.036"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2009.09.044"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2207899"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/15266028231197983"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2012.244"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/15266028211025023"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-24-0176"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.112.975318"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2019.05.006"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.70033","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccd.70033","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.70033","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T05:35:53Z","timestamp":1778996153000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.70033"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,24]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1002\/ccd.70033"],"URL":"https:\/\/doi.org\/10.1002\/ccd.70033","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"value":"1522-1946","type":"print"},{"value":"1522-726X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,24]]},"assertion":[{"value":"2025-05-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}