{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T06:09:06Z","timestamp":1778998146078,"version":"3.51.4"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T00:00:00Z","timestamp":1753228800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T00:00:00Z","timestamp":1753228800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Recently, Acurate neo2 (ACN2; Boston Scientific, US) and Sapien\u20103 series (Edwards Lifesciences, US) were compared in the IDE trial failing to demonstrate non\u2010inferiority of ACN2. The Myval series (MyV), an alternative balloon\u2010expandable device, demonstrated non\u2010inferiority compared to Sapien\u20103 and Evolut (Medtronic, US) in the LANDMARK trial. However, no direct comparison exists between ACN2 and MyV.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>We aimed to compare mid\u2010term clinical and hemodynamic outcomes of the ACN2 and MyV transcatheter heart valves.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This multicenter retrospective analysis included patients implanted with ACN2 and MyV series devices. The primary objective was to assess 1\u2010year mortality and stroke rates. Secondary outcomes included technical success, mortality, stroke, residual aortic regurgitation (AR), mean aortic gradients, and new permanent pacemaker implantation (PPI) rates up to 4 years. A matched comparison adjusting for clinical and anatomical characteristics was performed and echocardiograms were centrally analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 545 patients (ACN2: 144; MyV: 401) from nine institutions were included. Matched technical\u00a0success rates were 87.6% and 94.4%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.180 (90.3% for ACN2 and 97% for MyV;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001 in unmatched). In\u2010hospital matched PPI rates were 10.1% for ACN2 and 9% for MyV. At 4 years, matched residual \u2265\u2009moderate AR rates were similar (ACN2: 15.8% vs. MyV: 21.1%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.706), though ACN2 showed better mean aortic gradients (9.2\u2009\u00b1\u20094.2 vs. 13.1\u2009\u00b1\u20095.4,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001) and effective orifice area. Unmatched mortality + stroke rates were comparable but lower for ACN2 after matching (3.4% vs. 15.7%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005). Importantly, cardiovascular mortality (3.4% for ACN2 and 5.6% for MyV,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.720) and valve\u2010related deaths were comparable.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>ACN2 showed superior long\u2010term hemodynamics and lower matched 4\u2010year mortality and stroke rates, though cardiovascular mortality and valve\u2010related deaths were comparable.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.70034","type":"journal-article","created":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T05:55:04Z","timestamp":1753336504000},"page":"2005-2017","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of Self\u2010Expandable Acurate Neo\u20102 and Balloon\u2010Expandable Myval Transcatheter Heart Valves at 4\u2010Year Follow\u2010Up"],"prefix":"10.1002","volume":"106","author":[{"given":"Akash","family":"Jain","sequence":"first","affiliation":[{"name":"Cardiology Department University Clinic Hospital of Valladolid Valladolid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2849-815X","authenticated-orcid":false,"given":"John","family":"Jose","sequence":"additional","affiliation":[{"name":"Christian Medical College Vellore India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9732-9459","authenticated-orcid":false,"given":"Matteo","family":"Montorfano","sequence":"additional","affiliation":[{"name":"School of Medicine Vita\u2010Salute San Raffaele University Milan Italy"},{"name":"Interventional Cardiology Unit IRCCS San Raffaele Scientific Institute Milan 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