{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T07:01:15Z","timestamp":1771225275318,"version":"3.50.1"},"reference-count":6,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T00:00:00Z","timestamp":1753401600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T00:00:00Z","timestamp":1753401600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Guiding\u2010extension catheters (GECs) provide enhanced support to guiding catheter (GC) during complex percutaneous coronary intervention (PCI). However, by reducing the inner cross\u2010sectional diameter, they can create high friction between the GEC and the drug\u2010eluting stents (DES), potentially causing abrasion and damage to the abluminal struts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This study aims to compare the performances of the Amphilimus Cre8 EVO polymer\u2010free DES with all the other surface\u2010coated DES. The abluminal grooves of this polymer\u2010free DES, which contain the drug and avoid any risk of its abrasion and detachment (abluminal reservoir technology), may offer a protective effect during stent advancement within the GEC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Between January 2019 and April 2024, 218 patients who underwent complex PCI procedures with the insertion of a DES and the use of GEC were enrolled in the study. They were divided into Group A (39 patients) received the Amphilimus polymer\u2010free DES, while Group B (179 patients) received other types of DES. To evaluate the efficacy and safety of the DES used, a device\u2010oriented composite endpoint (DoCE) was assessed at one year of follow\u2010up. This composite endpoint included Cardiovascular Death, Target Vessel Myocardial Infarction, and Clinically and Physiologically indicated Target Lesion Revascularization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At the one\u2010year follow\u2010up, the primary endpoint demonstrated a statistically significant difference between the two groups. Event\u2010free survival from DoCE was 97.4% in Group A compared to 85.5% in Group B (Log rank = 0.027). Additionally, there was a significant difference in mean stent length between the groups: Group A had a longer mean stent length of 52.4 \u00b1 38.6 mm, while Group B had a mean length of 40.4 \u00b1 22.6 mm, with a\n                      <jats:italic>p<\/jats:italic>\n                      \u2010value of 0.01. All other clinical and procedural variables were similar between the two groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings suggest that the polymer\u2010free DES tested in this study appears to be the most effective option when using GECs, as it may help prevent negative interactions between the inner surface of GEC and the abluminal struts of the DES.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.70035","type":"journal-article","created":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T10:49:38Z","timestamp":1753440578000},"page":"2119-2122","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Interaction Between Guiding\u2010Extension Catheter and Drug\u2010Eluting Stents: Always Safe or Sometimes Harmful?"],"prefix":"10.1002","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2067-6265","authenticated-orcid":false,"given":"Salvatore","family":"Colangelo","sequence":"first","affiliation":[{"name":"Cardiovascular Intervention San Giovanni Bosco Hospital Torino Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1867-8253","authenticated-orcid":false,"given":"Riccardo","family":"Mangione","sequence":"additional","affiliation":[{"name":"Cardiovascular Intervention San Giovanni Bosco Hospital Torino Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Iannaccone","sequence":"additional","affiliation":[{"name":"Cardiovascular Intervention San Giovanni Bosco Hospital Torino Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Colombo","sequence":"additional","affiliation":[{"name":"Cardiovascular Intervention San Giovanni Bosco Hospital Torino Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giacomo Giovanni","family":"Boccuzzi","sequence":"additional","affiliation":[{"name":"Cardiovascular Intervention San Giovanni Bosco Hospital Torino Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ihj.2021.09.011"},{"key":"e_1_2_8_3_1","unstructured":"S.Colangelo\u201cPCI in Tortuous and Difficult to Access Coronary Arteries \u201d Personal Data presented at EuroPCR 2024 Paris."},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2021.08.078"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-24-00657"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2015.09.020"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab790"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.70035","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccd.70035","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.70035","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T06:01:57Z","timestamp":1771221717000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.70035"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,25]]},"references-count":6,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1002\/ccd.70035"],"URL":"https:\/\/doi.org\/10.1002\/ccd.70035","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"value":"1522-1946","type":"print"},{"value":"1522-726X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,25]]},"assertion":[{"value":"2025-02-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}