{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T22:25:02Z","timestamp":1788387902054,"version":"build-2803163510"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T00:00:00Z","timestamp":1753142400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T00:00:00Z","timestamp":1753142400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Left atrial appendage closure (LAAC) is a well\u2010established alternative for stroke prevention in patients with atrial fibrillation (AF) who are not suitable for long\u2010term anticoagulation. The WATCHMAN FLX Pro 40\u2009mm device is a novel advancement featuring a fluoropolymer coating to enhance thromboresistance and a size expansion to accommodate larger left atrial appendages (LAA). However, clinical data on this new device remains limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study presents the first case series evaluating the procedural success, safety, and early outcomes of the 40\u2009mm WATCHMAN FLX Pro device.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of nine patients underwent LAAC with the 40\u2009mm WATCHMAN FLX Pro between July and November 2024. Pre\u2010procedural imaging, intraoperative guidance, procedural outcomes, and follow\u2010up imaging were analyzed. Procedural success was defined by the successful deployment of the device meeting \u201cPASS\u201d criteria, with no major complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The study demonstrated a 100% procedural success rate, with all patients undergoing same\u2010day discharge. No procedural or periprocedural complications were observed. Follow\u2010up imaging at 4 months (available for 88.9% of patients) revealed no high\u2010grade device\u2010related thrombus (DRT), though some cases exhibited peridevice leaks, predominantly minor subfabric leaks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The 40\u2009mm WATCHMAN FLX Pro expands LAAC treatment options for patients with larger LAA anatomy, demonstrating a favorable safety and efficacy profile in this early experience. Larger studies with long\u2010term follow\u2010up are needed to validate these findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.70036","type":"journal-article","created":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T05:18:48Z","timestamp":1753247928000},"page":"1986-1992","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Evaluating the New Watchman FLX Pro 40\u2009mm Device: A Case Study Series"],"prefix":"10.1002","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4287-3371","authenticated-orcid":false,"given":"Philippe","family":"Taieb","sequence":"first","affiliation":[{"name":"Harrington Heart &amp; Vascular Institute University Hospitals Cleveland Medical Center Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6543-7567","authenticated-orcid":false,"given":"Marco","family":"Frazzetto","sequence":"additional","affiliation":[{"name":"Harrington Heart &amp; Vascular Institute University Hospitals Cleveland Medical Center Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro Soares","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Harrington Heart &amp; Vascular Institute University Hospitals Cleveland Medical Center Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8364-1732","authenticated-orcid":false,"given":"Steven J.","family":"Filby","sequence":"additional","affiliation":[{"name":"Harrington Heart &amp; Vascular Institute University Hospitals Cleveland Medical Center Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-19-00128"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.050117"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euac270"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.04.029"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61343-X"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.09.064"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.123.013750"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13164651"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2023.04.013"},{"key":"e_1_2_9_11_1","volume-title":"European Heart Journal: Case Reports","author":"Nielsen\u2010Kudsk J. 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