{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T06:09:01Z","timestamp":1778998141508,"version":"3.51.4"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T00:00:00Z","timestamp":1753142400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T00:00:00Z","timestamp":1753142400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>We aimed to externally validate the PRECISE\u2010DAPT cancer score which showed better accuracy in predicting bleeding events in patients with cancer than the original PRECISE\u2010DAPT score.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We used data from the BleeMACS (Bleeding complications in a Multicenter registry of patients discharged after an Acute Coronary Syndrome) project. We compared the performance and clinical usefulness of the original score and the cancer score by calculating the C\u2010statistic, the net reclassification index (NRI), and decision curve analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 13,932 patients were included, of which 864 patients had a diagnosis of cancer at the time of presentation with an AMI. According to the original PRECISE DAPT score, 63.3% of patients with cancer were classified as HBR, whereas 94.9% of patients with cancer were classified as HBR according to the cancer score. Cox\u2010regression models showed that patients classified as HBR by the updated cancer score have higher odds of bleeding (HR 2.6, 95% CI 2.1\u22123.1) events than patients classified as HBR by the original score (HR 2.2, 95% CI 1.8\u22122.7). The cancer score showed higher discrimination ability (C\u2010statistic 0.66) than the original score (C\u2010statistic 0.64). The overall NRI of the cancer score was 2.7%. The decision curves analysis showed that the cancer score use is roughly identical to the original score in patients without cancer but superior to the original score in patients with cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The PRECISE\u2010DAPT cancer score is a valid and useful tool for the prediction of bleeding risk in patients with cancer and presenting with AMI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.70040","type":"journal-article","created":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T08:34:07Z","timestamp":1753173247000},"page":"1912-1919","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["External Validation of the PRECISE\u2010DAPT Cancer Score in Patients With Acute Myocardial Infarction"],"prefix":"10.1002","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4625-2775","authenticated-orcid":false,"given":"Mohamed","family":"Dafaalla","sequence":"first","affiliation":[{"name":"Keele Cardiovascular Research Group, Centre for Prognosis Research Keele University Stoke\u2010on\u2010Trent UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3097-2834","authenticated-orcid":false,"given":"Francesco","family":"Costa","sequence":"additional","affiliation":[{"name":"Cardiology Department University Hospital Virgen de la Victoria, Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga (IBIMA) M\u00e1laga Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Enfermedades Cardiovasculares (CIBERCV) Instituto de Salud Carlos III Madrid 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Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Bironzo","sequence":"additional","affiliation":[{"name":"Department of Oncology, San Luigi Hospital University of Turin Orbassano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio Raposeiras","family":"Roub\u00ed","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hospital \u00c1lvaro Cunqueiro Vigo Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ovidio","family":"De Filippo","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Cardiovascular and Thoracic Department \u201cCitt\u00e0 della Salute e della Scienza\u201d Hospital Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabrizio","family":"D'Ascenzo","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences University of Turin Turin 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