{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T06:08:08Z","timestamp":1778998088778,"version":"3.51.4"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T00:00:00Z","timestamp":1753228800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T00:00:00Z","timestamp":1753228800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To explore the clinical efficacy and safety of interventional closure of patent ductus arteriosus (PDA) via femoral venous puncture under echocardiography guidance at high altitude.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>From December 2022 to July 2023, 36 patients with PDA at high altitude were prospectively enrolled and underwent closure either under echocardiography guidance or fluoroscopy guidance. Baseline, procedural, and outcome characteristics were compared in intention\u2010to\u2010treat analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The characteristics of patients and PDA were comparable between the two groups. The success rate of occlusion was 100% in both groups. Compared with the traditional fluoroscopy group, the echocardiography group showed a significant reduction in Air Kerma (112.13\u2009\u00b1\u200977.51\u2009Gy vs. 247.27\u2009\u00b1\u2009123.81\u2009Gy,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001), Dose Area Product (24.3 [13.6\u201331.3] Gy\u00b7cm\n                      <jats:sup>2<\/jats:sup>\n                      vs. 41.5 [26.9\u201363.5] Gy\u00b7cm\n                      <jats:sup>2<\/jats:sup>\n                      ,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.015) and intraoperative contrast dose (0 vs. 1.74\u2009\u00b1\u20091.02\u2009mL\/kg,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). In the fluoroscopy group, a significant rise in creatinine (60.47\u2009\u00b1\u200914.02 umol\/L vs. 40.93\u2009\u00b1\u200914.94 umol\/L,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and urea nitrogen levels (6.03\u2009\u00b1\u20091.12\u2009mmol\/L vs. 4.80\u2009\u00b1\u20090.81\u2009mmol\/L,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) at 24\u2009h postoperatively were detected compared to preoperative levels, whereas no such changes were detected in the echocardiography group. Except for one patient in the fluoroscopy group lost to 1\u2010year follow\u2010up, no adverse events were reported in either group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>At high altitude, echocardiography\u2010guided percutaneous PDA closure offers comparable efficacy to traditional methods, with minimal X\u2010ray exposure and no contrast\u2010induced kidney injury.<\/jats:p>\n                    <jats:p>\n                      Clinical Trial Registration: The trial is registered at\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.chictr.org.cn\">http:\/\/www.chictr.org.cn<\/jats:ext-link>\n                      (ChiCTR2400090901).\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.70044","type":"journal-article","created":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T10:39:30Z","timestamp":1753267170000},"page":"1979-1985","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Echocardiography\u2010Guided Percutaneous Patent Ductus Arteriosus Closure: A Prospective Trial at High Altitude"],"prefix":"10.1002","volume":"106","author":[{"given":"Hongliang","family":"Wei","sequence":"first","affiliation":[{"name":"Tibet Autonomous Region People's Hospital Lhasa China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luxi","family":"Guan","sequence":"additional","affiliation":[{"name":"Fuwai Hospital, National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong","family":"Luo","sequence":"additional","affiliation":[{"name":"Fuwai Hospital, National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengwei","family":"Li","sequence":"additional","affiliation":[{"name":"Fuwai Hospital, National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Ni","sequence":"additional","affiliation":[{"name":"Tibet Autonomous Region People's Hospital Lhasa China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1837-8709","authenticated-orcid":false,"given":"Zhuoga","family":"Danzeng","sequence":"additional","affiliation":[{"name":"Tibet Autonomous Region People's Hospital Lhasa China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng","family":"Ban","sequence":"additional","affiliation":[{"name":"Tibet Autonomous Region People's Hospital Lhasa China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangbin","family":"Pan","sequence":"additional","affiliation":[{"name":"Fuwai Hospital, National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luobu","family":"Gesang","sequence":"additional","affiliation":[{"name":"Tibet Autonomous Region People's Hospital Lhasa China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5385-7724","authenticated-orcid":false,"given":"Haibo","family":"Hu","sequence":"additional","affiliation":[{"name":"Fuwai Hospital, National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,23]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.592063"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.43.3.323"},{"key":"e_1_2_11_4_1","first-page":"3120","article-title":"[Susceptibility of Patients With Congenital Heart Disease to Pulmonary Hypertension at a High Altitude]","volume":"91","author":"Chen Q. 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