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Transcatheter PFO closure is the gold standard for recurrent embolism with significant inter\u2010atrial shunting, with recent trials confirming its superiority in reducing ischemic stroke recurrence over medical therapy. However, device\u2010related thrombosis remains a concern, posing risks of systemic embolism and neurological events. Optimal post\u2010closure antithrombotic management, including the choice and duration of therapy, remains unclear. Recommendations suggest transient dual antiplatelet therapy followed by long\u2010term single therapy, but robust evidence is lacking, especially regarding device neo\u2010endothelization timelines. Current studies often lack long\u2010term follow\u2010up, leaving gaps in understanding the incidence and prevention of thrombosis. Future research is crucial to provide evidence\u2010based guidance and refine personalized treatment strategies for better outcomes.<\/jats:p>","DOI":"10.1002\/ccd.70049","type":"journal-article","created":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T06:15:31Z","timestamp":1753337731000},"page":"2037-2047","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Navigating the Uncertainties of Antithrombotic Therapy After Transcatheter Patent Foramen Ovale Closure: A Comprehensive Review"],"prefix":"10.1002","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0464-3607","authenticated-orcid":false,"given":"Eirini","family":"Beneki","sequence":"first","affiliation":[{"name":"First Cardiology Department, School of Medicine, Hippokration General Hospital National and Kapodistrian University of Athens Athens Greece"},{"name":"Department of Cardiology Lausanne University Hospital (CHUV) Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3186-8905","authenticated-orcid":false,"given":"Kyriakos","family":"Dimitriadis","sequence":"additional","affiliation":[{"name":"First Cardiology Department, School of Medicine, Hippokration General Hospital National and Kapodistrian University of Athens Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos","family":"Pyrpyris","sequence":"additional","affiliation":[{"name":"First Cardiology Department, School of Medicine, Hippokration General Hospital National and Kapodistrian University of Athens Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios","family":"Tzimas","sequence":"additional","affiliation":[{"name":"Department of Cardiology Lausanne University Hospital (CHUV) Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4374-0389","authenticated-orcid":false,"given":"Ioannis","family":"Skalidis","sequence":"additional","affiliation":[{"name":"Institut Cardiovasculaire Paris Sud (ICPS) Essonne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Meier","sequence":"additional","affiliation":[{"name":"Department of Cardiology Lausanne University Hospital (CHUV) Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panagiotis","family":"Antiochos","sequence":"additional","affiliation":[{"name":"Department of Cardiology Lausanne University Hospital (CHUV) Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panagiotis","family":"Kostakis","sequence":"additional","affiliation":[{"name":"First Cardiology Department, School of Medicine, Hippokration General Hospital National and Kapodistrian University of Athens Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Efthymia","family":"Pavlou","sequence":"additional","affiliation":[{"name":"Laboratory of Reliability and Quality Control in Laboratory Hematology (HemQcR), Department of Biomedical Sciences, School of Health &amp; 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