{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T07:00:45Z","timestamp":1771225245159,"version":"3.50.1"},"reference-count":13,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T00:00:00Z","timestamp":1753747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T00:00:00Z","timestamp":1753747200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Pulmonary arterial hypertension (PAH) is a life\u2010threatening condition characterized by significantly elevated pulmonary artery pressure (PAP) and resistance. While targeted drugs can alleviate symptoms, their long\u2010term efficacy is limited, and treatment is often associated with notable side effects and financial burden. Percutaneous pulmonary artery denervation (PADN) offers a novel interventional approach for PAH patients with inadequate responses to targeted therapy by selectively ablating sympathetic nerves and restoring neurohumoural balance. This case report describes a 67\u2010year\u2010old male with severe PAH who underwent PADN after showing a poor response to long\u2010term macitentan and tadalafil therapy. Immediate postprocedure haemodynamics revealed a reduction in mean PAP (mPAP) from 42\u2009mmHg to 32\u2009mmHg and a 16% decline in pulmonary vascular resistance (PVR; 10.10 to 8.48 Wood units). A 6\u2010month follow\u2010up demonstrated sustained improvements in the 6\u2010min walk distance (6MWT), WHO functional class, Borg dyspnoea index, and NT\u2010proBNP levels. Clinical studies have confirmed that PADN can significantly improve the haemodynamics and exercise tolerance of medium\u2010 to high\u2010risk PAH patients by inhibiting excessive sympathetic nervous system activity and promoting pulmonary vasodilation, especially when combined with targeted drugs, which can produce synergistic effects. However, large\u2010index trials are needed to validate its long\u2010term efficacy, expanded indications, and procedural standardization.<\/jats:p>","DOI":"10.1002\/ccd.70058","type":"journal-article","created":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T05:49:31Z","timestamp":1753854571000},"page":"2218-2223","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pulmonary Artery Denervation for Idiopathic Pulmonary Arterial Hypertension: A Case Report"],"prefix":"10.1002","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-0965-2931","authenticated-orcid":false,"given":"Gou","family":"Junqi","sequence":"first","affiliation":[{"name":"Department of Cardiology, Geriatric Diseases Institute of Chengdu\/Cancer Prevention and Treatment Institute of Chengdu, Chengdu Fifth People\u2032s Hospital, The Second Clinical Medical College Affiliated Fifth People's Hospital of Chengdu University of Traditional Chinese Medicine Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liu","family":"Chaohui","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Geriatric Diseases Institute of Chengdu\/Cancer Prevention and Treatment Institute of Chengdu, Chengdu Fifth People\u2032s Hospital, The Second Clinical Medical College Affiliated Fifth People's Hospital of Chengdu University of Traditional Chinese Medicine Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao","family":"Fengyou","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Geriatric Diseases Institute of Chengdu\/Cancer Prevention and Treatment Institute of Chengdu, Chengdu Fifth People\u2032s Hospital, The Second Clinical Medical College Affiliated Fifth People's Hospital of Chengdu University of Traditional Chinese Medicine Chengdu 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