{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T22:07:45Z","timestamp":1791410865211,"version":"4.3.3"},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T00:00:00Z","timestamp":1753747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T00:00:00Z","timestamp":1753747200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The choice of transcatheter heart valve (THV) platform, including self\u2010expanding valves (SEVs) and balloon\u2010expandable valves (BEVs), may influence outcomes in patients with peripheral artery disease (PAD) undergoing transfemoral transcatheter aortic valve replacement (TAVR). This relationship remains underexplored in high\u2010risk populations with challenging vascular access.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study assessed the impact of SEVs and BEVs on clinical outcomes in PAD patients, considering hostile score severity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This sub\u2010analysis of the Hostile Registry included 419 TAVR patients (47% SEVs, 53% BEVs). Outcomes, including all\u2010cause mortality, stroke, vascular complications, and major bleeding were evaluated at 30 days and 1 year. Logistic regression and Cox proportional hazard models assessed associations, with interaction terms exploring the modifying effect of valve type by hostile score severity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      No significant differences emerged between SEVs and BEVs for 30\u2010day and 1\u2010year outcomes. However, in SEVs recipients, a high hostile score was associated with worse outcomes, including 1\u2010year all\u2010cause mortality (HR 2.81,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.033), stroke (HR 18.26,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.008), major bleeding (HR 2.49,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.033), and MACCE (HR 4.34,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Interaction terms were not statistically significant, although a trend for MACCE (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0598) was noted.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>SEVs and BEVs demonstrated comparable outcomes overall, high hostile score were associated with worse outcomes in the SEV group. Nonetheless, there was a trend suggesting a difference between the two valves in this setting, and further studies are needed to confirm potential valve\u2010specific differences in high\u2010risk populations and to refine personalized valve selection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.70061","type":"journal-article","created":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T05:55:16Z","timestamp":1753854916000},"page":"2189-2200","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Impact of THV Platforms on Transfemoral TAVR in Complex Vascular Access: Insights From the Hostile Registry"],"prefix":"10.1002","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3972-4642","authenticated-orcid":false,"given":"Chiara","family":"Fraccaro","sequence":"first","affiliation":[{"name":"Interventional Cardiology Unit, Department of Cardiac, Thoracic and Vascular Sciences Padua University Hospital Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tullio","family":"Palmerini","sequence":"additional","affiliation":[{"name":"Cardiology Unit, Cardiac Thoracic and Vascular Department IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna Bologna Italy"},{"name":"Cardiac, Thoracic and Vascular Department Universit\u00e0 di Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Lorenzoni","sequence":"additional","affiliation":[{"name":"Unit of Biostatistics, Epidemiology and Public Health, Department of Cardiac, Thoracic and Vascular Sciences University of Padova Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9969-2649","authenticated-orcid":false,"given":"Francesco","family":"Saia","sequence":"additional","affiliation":[{"name":"Cardiology Unit, Cardiac Thoracic and Vascular Department IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna Bologna Italy"},{"name":"Cardiac, Thoracic and Vascular Department Universit\u00e0 di Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won\u2010Keun","family":"Kim","sequence":"additional","affiliation":[{"name":"Kerckhoff Heart Center Bad Nauheim Germany"},{"name":"Cardiology &amp; Angiology Justus\u2010Liebig\u2010University of Giessen Giessen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Iadanza","sequence":"additional","affiliation":[{"name":"UOC Cardiologia Interventistica Azienda Ospedaliera Universitaria Senese Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9674-0278","authenticated-orcid":false,"given":"Ole","family":"De Backer","sequence":"additional","affiliation":[{"name":"Heart Center, Rigshospitalet Copenhagen University Hospital Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Burzotta","sequence":"additional","affiliation":[{"name":"U.O.C. di Interventistica Cardiologica e Diagnostica Invasiva Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Universit\u00e0 Cattolica del Sacro Cuore Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Trani","sequence":"additional","affiliation":[{"name":"U.O.C. di Interventistica Cardiologica e Diagnostica Invasiva Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Universit\u00e0 Cattolica del Sacro Cuore Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas M.","family":"Van Mieghem","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Thoraxcenter Erasmus University Medical Center Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Pilgrim","sequence":"additional","affiliation":[{"name":"Inselspital, Bern University Hospital University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5880-8278","authenticated-orcid":false,"given":"Tiziana Claudia","family":"Aranzulla","sequence":"additional","affiliation":[{"name":"A.O. Mauriziano Umberto I Hospital Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max M.","family":"Meertens","sequence":"additional","affiliation":[{"name":"Klinik III f\u00fcr Innere Medizin\u2010Kardiologie, Pneumologie und Internistische Intensivmedizin University Hospital Cologne\u2013Heart Center Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Joner","sequence":"additional","affiliation":[{"name":"German Heart Centre Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2719-5146","authenticated-orcid":false,"given":"Francesco","family":"Meucci","sequence":"additional","affiliation":[{"name":"Cardiothoracovascular Department, Division of Structural Interventional Cardiology Careggi University Hospital Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Toggweiler","sequence":"additional","affiliation":[{"name":"Cardiology Heart Center Lucerne Lucerne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4687-3686","authenticated-orcid":false,"given":"Luca","family":"Testa","sequence":"additional","affiliation":[{"name":"Department of Cardiology IRCCS Policlinico San Donato Milan Italy"},{"name":"San Raffaele Research Hospital \u201cVita e Salute\u201d University Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Berti","sequence":"additional","affiliation":[{"name":"Unit of Diagnostic and Interventional Cardiology C.N.R. Reg. Toscana G. Monasterio Foundation, Ospedale del Cuore Massa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Montorfano","sequence":"additional","affiliation":[{"name":"Department of Cardiology IRCCS Policlinico San Donato Milan Italy"},{"name":"Interventional Cardiology Unit IRCCS San Raffaele Scientific Institute Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Braun","sequence":"additional","affiliation":[{"name":"Department of Medicine I, University Hospital Munich, Medical Faculty Ludwig Maximilian University of Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fausto","family":"Castriota","sequence":"additional","affiliation":[{"name":"Cardioangiology Cath Lab Cotignola Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5763-9804","authenticated-orcid":false,"given":"Marco","family":"De 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and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.70061","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccd.70061","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.70061","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T06:01:38Z","timestamp":1771221698000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.70061"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,29]]},"references-count":19,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1002\/ccd.70061"],"URL":"https:\/\/doi.org\/10.1002\/ccd.70061","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"value":"1522-1946","type":"print"},{"value":"1522-726X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,29]]},"assertion":[{"value":"2025-04-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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