{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T07:01:08Z","timestamp":1771225268041,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T00:00:00Z","timestamp":1754352000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T00:00:00Z","timestamp":1754352000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Physiological pattern of coronary artery disease, whether focal or diffuse, is critical in guiding physicians during the decision\u2010making process for percutaneous coronary interventions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study introduces two novel non\u2010hyperemic coronary physiology indices designed for longitudinal vessel analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this prospective observational study, 415 patients underwent pressure\u2010wire functional assessments using instantaneous wave\u2010free ratio (iFR) pullback traces between March 2015 and November 2023 at Verona University Hospital. After applying exclusion criteria, the final study population comprised 198 patients with 209 intermediate coronary lesions. Vessels were qualitatively categorized as focal, diffuse, mixed\u2010focal, or mixed\u2010diffuse based on expert panel interpretation. The novel iFR Pullback Pressure Gradient (iPG) was derived from pullback curves to quantify the atherosclerotic pattern along the vessel. The local severity of lesions was assessed using the instantaneous iFR gradients per unit of length (diFR\/ds). Additionally, based on Murray law\u2010based Quantitative Flow Ratio (\u00b5FR), both \u00b5FR\u2010PPGi and d\u00b5FR\/ds were computed, to evaluate their correlation with iFR\u2010derived metrics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The optimal iPG threshold for defining focal disease was 0.71 (Youden index = 0.456), demonstrating good accuracy in predicting the predominant disease pattern (AUC 0.785,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). iPG provided an accuracy of 72%, with a sensitivity, specificity, positive predictive value, negative predictive value of 86.5%, 59%, 67.6%, 81.5%, respectively. The \u00b5FR\u2010PPGi and d\u00b5FR\/ds showed significant correlations with iPG and diFR\/ds, respectively (r\u2009=\u20090.238,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001; r\u2009=\u20090.528,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>iPG and diFR\/ds are novel quantitative indices for assessing physiological patterns of coronary artery disease, without the need for hyperemia induction. Moderate agreement between angio\u2010 and iFR\u2010based indices was found.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.70065","type":"journal-article","created":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T12:58:15Z","timestamp":1754398695000},"page":"2374-2385","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Novel Non\u2010Hyperemic Coronary Physiology Indices for Vessel Longitudinal Analysis"],"prefix":"10.1002","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2755-2094","authenticated-orcid":false,"given":"Simone","family":"Fezzi","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Medicine University of Verona Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6942-355X","authenticated-orcid":false,"given":"Guy F. A.","family":"Prado","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine University of Verona Verona Italy"},{"name":"Department of Clinical and Molecular Medicine Sapienza University Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6486-4702","authenticated-orcid":false,"given":"Luigi Alberto","family":"Iossa","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine University of Verona Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daixin","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Cardiology Ren Ji Hospital, School of Medicine and School of Biomedical Engineering Shanghai Jiao Tong University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabetta","family":"Pianezzola","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine University of Verona Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico Cesar","family":"Vigo","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine University of Verona Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3638-200X","authenticated-orcid":false,"given":"Paolo Alberto Del","family":"Sole","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine University of Verona Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Verdiana","family":"Galli","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine University of Verona Verona Italy"},{"name":"Department of Clinical and Molecular Medicine Sapienza University Rome 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