{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T19:10:12Z","timestamp":1762283412645,"version":"build-2065373602"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>In\u2010stent restenosis (ISR) is a common complication following coronary stent implantation. Intracoronary brachytherapy (ICBT) has re\u2010emerged as an effective treatment modality. However, optimal procedural strategies, including the role of radiation source overlap and adequate margin length, remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To evaluate the impact of radiation source overlap and radiation margin adequacy on procedural and clinical outcomes in patients undergoing ICBT for ISR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective, single\u2010center study of 222 patients treated with ICBT for ISR between June 2016 and December 2024. Patients were stratified using radiation source overlap (single vs. double dwell) and radiation margin length (&lt;\u200910 vs. \u2265\u200910\u2009mm). The primary endpoint was 1\u2010year target lesion revascularization (TLR). Secondary endpoints included 1\u2010year and 3\u2010year all\u2010cause mortality and 1\u2010year major adverse cardiovascular events (MACE).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 222 patients (mean age 65.1\u2009\u00b1\u20090.7 years; 28.9% female), 42 (19.3%) received overlapping radiation, and 1616 (74.8%) had radiation margins \u2265\u200910\u2009mm. TLR rates at 1 year were similar between overlap and non\u2010overlap groups (HR\u2009=\u20091.26, 95% CI [0.68\u22122.31],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.46). There were no significant differences in 1\u2010year mortality (HR\u2009=\u20090.79; 95% CI [0.27\u20132.29];\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.67) or 1\u2010year MACE (HR\u2009=\u20091.17; 95% CI [0.66\u20132.10];\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.59). Patients with margins \u2265\u200910\u2009mm had similar rates of 1\u2010year TLR compared to those with margins &lt;\u200910\u2009mm (HR\u2009=\u20090.61; 95% CI [0.16\u22122.30],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.47). Both groups were associated with rates of 1\u2010year mortality (HR\u2009=\u20090.73, 95% CI [0.33\u22121.60],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.43) and 1\u2010year MACE (HR\u2009=\u20090.98; 95% CI [0.63\u22121.53],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.94).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Radiation source overlap and short (&lt;\u200910\u2009mm) or extended (\u2265\u200910\u2009mm) treatment margins beyond the restenotic lesion do not compromise the safety or efficacy of ICBT. These findings support a more individualized, anatomy\u2010guided approach to ICBT planning, which may enhance procedural feasibility without sacrificing long\u2010term outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.70113","type":"journal-article","created":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T05:50:19Z","timestamp":1756792219000},"page":"2870-2879","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Outcomes of Radiation Overlap and Margin Length in Intracoronary Brachytherapy for In\u2010Stent Restenosis"],"prefix":"10.1002","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-2680-7047","authenticated-orcid":false,"given":"Chloe","family":"Kharsa","sequence":"first","affiliation":[{"name":"Department of Cardiology Houston Methodist DeBakey Heart &amp; Vascular Center Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Devin","family":"Olek","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Houston Methodist Hospital Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0383-6471","authenticated-orcid":false,"given":"Gal","family":"Sella","sequence":"additional","affiliation":[{"name":"Department of Cardiology Houston Methodist DeBakey Heart &amp; Vascular Center Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mangesh","family":"Kritya","sequence":"additional","affiliation":[{"name":"Department of Cardiology Houston Methodist DeBakey Heart &amp; Vascular Center Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Elias","sequence":"additional","affiliation":[{"name":"Department of Cardiology Houston Methodist DeBakey Heart &amp; Vascular Center Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad Faraz","family":"Anwaar","sequence":"additional","affiliation":[{"name":"Department of Cardiology Houston Methodist DeBakey Heart &amp; Vascular Center Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elia El","family":"Hajj","sequence":"additional","affiliation":[{"name":"Department of Cardiology Houston Methodist DeBakey Heart &amp; Vascular Center Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9857-0519","authenticated-orcid":false,"given":"Albert E.","family":"Raizner","sequence":"additional","affiliation":[{"name":"Department of Cardiology Houston Methodist DeBakey Heart &amp; Vascular Center Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Teh","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Houston Methodist Hospital Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Farach","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Houston Methodist Hospital Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4334-8133","authenticated-orcid":false,"given":"Neal S.","family":"Kleiman","sequence":"additional","affiliation":[{"name":"Department of Cardiology Houston Methodist DeBakey Heart &amp; Vascular Center Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8600-6352","authenticated-orcid":false,"given":"Alpesh","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Cardiology Houston Methodist DeBakey Heart &amp; Vascular Center Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brachy.2022.05.004"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carrev.2023.01.019"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2024.12.003"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9149(96)00488-2"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0735-1097(01)01381-x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brachy.2024.11.006"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000033820.68791.3d"},{"volume-title":"StatPearls","year":"2025","author":"Omeh D. J.","key":"e_1_2_9_9_1"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)02108-3"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.685313"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.009449"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00059-001-2332-9"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1522-1865(98)00003-1"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(01)02712-2"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1053\/clon.2002.0070"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1522-1865(02)00133-6"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0735-1097(01)01112-3"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.103.12.e65"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2025.02.024"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jscai.2022.100550"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carrev.2025.06.022"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.70113","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T19:05:08Z","timestamp":1762283108000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.70113"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":21,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1002\/ccd.70113"],"URL":"https:\/\/doi.org\/10.1002\/ccd.70113","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"type":"print","value":"1522-1946"},{"type":"electronic","value":"1522-726X"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"2025-05-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}