{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:09:51Z","timestamp":1791220191965,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T00:00:00Z","timestamp":1756166400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T00:00:00Z","timestamp":1756166400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The long\u2010term efficacy of drug\u2010coated balloons (DCBs) is reduced in calcified lesions. While intravascular ultrasound (IVUS)\u2010guided DCB endovascular therapy (EVT) has shown favorable results in femoropopliteal artery (FPA) disease, the prognostic significance of calcification type remains unclear. This study evaluated the impact of calcification types, as assessed by IVUS, on long\u2010term patency after successful DCB treatment of de novo FPA lesions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In a retrospective, single\u2010center study, 131 symptomatic patients with 150 de novo FPA lesions underwent successful IVUS\u2010guided IN.PACT DCB EVT (residual stenosis &lt;\u200930%). The median follow\u2010up was 1185 days. The primary endpoint was freedom from restenosis. Multivariable analysis was performed to identify factors associated with restenosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mean patient age was 74.4\u2009\u00b1\u20097.6 years, and 75.6% were male. Freedom from restenosis at 3 years differed significantly by calcification type: 78.3% in no calcification, 68.7% in deep calcification, and 43.4% in superficial\/nodular calcification (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Despite similar minimal lumen areas post\u2010procedure, superficial\/nodular calcification was independently associated with higher restenosis risk. Other significant predictors included dialysis\u2010dependent renal failure, isolated popliteal artery lesions, subintimal involvement on IVUS, calcified lesion length \u2265\u200980\u2009mm, and total DCB length \u2265\u2009200\u2009mm.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Superficial\/nodular calcification on IVUS is a major predictor of restenosis after successful DCB\u2010EVT for de novo FPA disease. These findings suggest a potential role for plaque modification or debulking strategies before DCB use in such lesions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.70117","type":"journal-article","created":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T10:28:55Z","timestamp":1756204135000},"page":"2744-2752","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Long\u2010Term Clinical Association of Superficial and Nodular Calcification on Intravascular Ultrasound\u2010Guided Successful Drug\u2010Coated Balloon Endovascular Therapy for De Novo Femoropopliteal Artery Disease"],"prefix":"10.1002","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0895-5146","authenticated-orcid":false,"given":"Ji Woong","family":"Roh","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Division of Cardiology Yonsei University College of Medicine and Cardiovascular Center, Yongin Severance Hospital Yongin Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7001-9220","authenticated-orcid":false,"given":"Masahiko","family":"Fujihara","sequence":"additional","affiliation":[{"name":"Department of Cardiology Nozaki Tokushukai Hospital Osaka Japan"},{"name":"Department of Medicine and Biosystemic Science Kyushu University Graduate School of Medical Science Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Yazu","sequence":"additional","affiliation":[{"name":"Department of Medical Engineering Nozaki Tokushukai Hospital Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3947-2892","authenticated-orcid":false,"given":"Tomofumi","family":"Tsukizawa","sequence":"additional","affiliation":[{"name":"Department of Cardiology Nozaki Tokushukai Hospital Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiaki","family":"Yokoi","sequence":"additional","affiliation":[{"name":"Department of Cardiology Nozaki Tokushukai Hospital Osaka 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