{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T19:10:28Z","timestamp":1762283428476,"version":"build-2065373602"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T00:00:00Z","timestamp":1756771200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hypertrophic cardiomyopathy (HCM) with left ventricular outflow tract (LVOT) obstruction poses significant clinical challenges. Although septal reduction therapy (SRT) is the first treatment strategy after medical therapy, mitral transcatheter edge\u2010to\u2010edge repair (M\u2010TEER) has been reported in the emerging literature to alleviate the LVOT obstruction related to mitral regurgitation (MR) and systolic anterior motion (SAM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>In this article, we aim to evaluate the efficacy and safety of M\u2010TEER in managing symptomatic HCM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a systematic review according to Cochrane Handbook and the PRISMA statement. We comprehensively searched Embase, PubMed, and Scopus from inception to September 5, 2024, to identify case reports where symptomatic HCM were managed by M\u2010TEER. The data extracted included patient demographics, procedural details, hemodynamics, and outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We identified 20 patients in the literature with symptomatic HCM who underwent M\u2010TEER. The average age was 73.06\u2009\u00b1\u200913.81 years, predominantly male, 60%. All patients had evidence of intermittent LVOT obstruction, MR, and SAM. NYHA III\u2212IV was the presenting symptom in 95% of the patients. M\u2010TEER was performed in all patients, resulting in a significant improvement in the LVOT gradient from 68.9\u2009\u00b1\u200934.4 to 12.35\u2009\u00b1\u20099.6\u2009mmHg, an average improvement in MR grade of 2.68, and a mean improvement in NYHA class of two. Nineteen patients had successful procedures, underscoring the potential of M\u2010TEER in treating symptomatic HCM, while one patient succumbed to cardiogenic shock.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>M\u2010TEER appears to be viable and safe for managing symptomatic HCM due to LVOT obstruction secondary to MR and SAM in patients where SRT is deemed unsuitable. However, more evidence in a larger scale is required to demonstrate its long\u2010term efficacy and outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.70132","type":"journal-article","created":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T07:07:12Z","timestamp":1756796832000},"page":"2831-2838","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mitral Transcatheter Edge\u2010to\u2010Edge Repair in Symptomatic Hypertrophic Cardiomyopathy: A Systematic Review"],"prefix":"10.1002","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1029-2559","authenticated-orcid":false,"given":"Ashraf","family":"Ahmed","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Yale University School of Medicine, Bridgeport Hospital Bridgeport Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabricio","family":"Webber","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine University of Miami Coral Gables Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hima Sanjana","family":"Perumalla","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine UMKC University Kansas City Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaun","family":"Abid","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yale University School of Medicine, Bridgeport Hospital Bridgeport Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0457-738X","authenticated-orcid":false,"given":"Muath","family":"Baniowda","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine UMKC University Kansas City Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Arango","sequence":"additional","affiliation":[{"name":"Department Cardiovascular Diseases Yale University School of Medicine, Bridgeport Hospital Bridgeport Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael David","family":"Dyal","sequence":"additional","affiliation":[{"name":"Department Interventional Cardiology University of Miami Coral Gables Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1710575"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001250"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000937"},{"key":"e_1_2_6_4_2","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1161\/CIR.0000000000000945.","DOI":"10.1161\/CIR.0000000000000945"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2023.10.075"},{"key":"e_1_2_6_6_1","doi-asserted-by":"crossref","unstructured":"S. A. Guigui C. Torres E. Escolar and C. G. Mihos \u201cSystolic Anterior Motion of the Mitral Valve in Hypertrophic Cardiomyopathy: A Narrative Review \u201dJournal of Thoracic Disease14 no. 6 2022: 2309\u20132325 https:\/\/doi-org.qulib.idm.oclc.org\/10.21037\/jtd-22-182.","DOI":"10.21037\/jtd-22-182"},{"issue":"9","key":"e_1_2_6_7_1","first-page":"4006","article-title":"Evaluation and Implications of Mitral Regurgitation Using cMRI in Patients With Hypertrophic Cardiomyopathy","volume":"27","author":"Muresan I. D.","year":"2023","journal-title":"European Review for Medical and Pharmacological Sciences"},{"key":"e_1_2_6_8_1","doi-asserted-by":"crossref","unstructured":"H. Hayashi S. K. Singh R. T. Hahn et al. \u201cMitral Regurgitation Mechanisms Related to Systolic Anterior Motion in Hypertrophic Cardiomyopathy \u201dJournal of Thoracic Disease16 no. 1 (2024): 26\u201339 https:\/\/doi-org.qulib.idm.oclc.org\/10.21037\/jtd-23-1206.","DOI":"10.21037\/jtd-23-1206"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2022.03.012"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.25270\/jic\/20.00157"},{"key":"e_1_2_6_11_1","doi-asserted-by":"crossref","unstructured":"C. Kimmelstiel K. D. Everett P. Jain et al. \u201cTranscatheter Mitral Intervention Relieves Dynamic Outflow Obstruction and Reduces Cardiac Workload in Hypertrophic Cardiomyopathy \u201dCirculation. Heart Failure15 no. 4 (2022): e009171 https:\/\/doi-org.qulib.idm.oclc.org\/10.1161\/CIRCHEARTFAILURE.121.009171.","DOI":"10.1161\/CIRCHEARTFAILURE.121.009171"},{"key":"e_1_2_6_12_1","doi-asserted-by":"crossref","unstructured":"U. Sch\u00e4fer F. Kreidel and C. Frerker \u201cMitraClip Implantation as a New Treatment Strategy Against Systolic Anterior Motion\u2010Induced Outflow Tract Obstruction in Hypertrophic Obstructive Cardiomyopathy \u201dHeart Lung & Circulation23 no. 5 (2014): e131\u2013e135 https:\/\/doi-org.qulib.idm.oclc.org\/10.1016\/j.hlc.2014.01.007.","DOI":"10.1016\/j.hlc.2014.01.007"},{"key":"e_1_2_6_13_1","doi-asserted-by":"crossref","unstructured":"U. Sch\u00e4fer C. Frerker T. 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