{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T01:17:55Z","timestamp":1792718275493,"version":"4.5.0"},"reference-count":77,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T00:00:00Z","timestamp":1756857600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Carotid artery stenosis is a significant risk factor for ischemic stroke. Two primary interventions, carotid artery stenting (CAS) and carotid endarterectomy (CEA), are commonly used to prevent stroke.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study systematically reviews and compares the efficacy and safety of CAS versus CEA in preventing stroke and other related outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A comprehensive search of medical databases such as MEDLINE, Web of Science, ScienceDirect, and Cochrane CENTRAL identified relevant studies comparing CAS and CEA. Meta\u2010analyses were conducted using a random\u2010effects model to pool risk ratios (RRs) with 95% confidence interval (CI). Heterogeneity was assessed using\n                      <jats:italic>I<\/jats:italic>\n                      \u2010squared statistic and publication bias were assessed using Egger's test and funnel plot.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      CAS was associated with a significantly higher risk of stroke (RR\u2009=\u20091.490, 95% CI: 1.282\u20131.731,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and a borderline higher risk of restenosis (RR\u2009=\u20091.257, 95% CI: 1.000\u20131.578,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.050) compared to CEA. However, CAS had a significantly lower risk of myocardial infarction (RR\u2009=\u20090.476, 95% CI: 0.341\u20130.664,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and cranial nerve palsy (RR\u2009=\u20090.079, 95% CI: 0.042\u20130.149,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). No significant differences were found in all\u2010cause mortality, TIA, or pulmonary embolus between CAS and CEA.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>While CAS reduces the risk of myocardial infarction and cranial nerve palsy, it is associated with a higher risk of stroke and restenosis compared to CEA. These findings highlight the importance of individualized treatment decisions based on patient risk profiles.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.70133","type":"journal-article","created":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T09:31:22Z","timestamp":1756891882000},"page":"2913-2934","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Carotid Artery Stenting Versus Carotid Endarterectomy for Carotid Artery Stenosis: Systematic Review and Meta\u2010Analysis of Randomized Controlled Trials"],"prefix":"10.1002","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-2113-5833","authenticated-orcid":false,"given":"Guangxu","family":"Chu","sequence":"first","affiliation":[{"name":"Department of Neurosurgery Shengli Oilfield Central Hospital Dongying 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