{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T14:19:42Z","timestamp":1791901182996,"version":"4.3.4"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T00:00:00Z","timestamp":1756771200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2025,11]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Existing literature highlights unfavorable outcomes for patients with cardiac conduction disorders and Pulmonary Hypertension (PH). However, limited data exist on complete heart block (CHB) outcomes in the context of group 2 PH.<\/jats:p>\n <\/jats:sec>\n \n Aims<\/jats:title>\n To utilize a large national inpatient dataset to evaluate the association between group 2 PH and hospitalization outcomes in patients with CHB.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n The 2016\u22122019 Nationwide readmissions database was queried to identify cases of CHB. In\u2010hospital outcomes were compared based on the presence vs absence of group 2 PH. The primary outcome was mortality. Secondary outcomes included odds of acute kidney injury (AKI), permanent pacemaker (PPM) and temporary pacemaker (TPM) use, cardiac arrest, all cause 30\u2010day readmissions, stroke, length of stay (LOS) and total charges (THC). Multivariable regression models adjusted for confounders.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Among 169,724 CHB cases, 316 (0.2%) had a secondary diagnosis of group 2 PH. Group 2 PH was associated with a higher mortality during index hospitalization compared to the patients without PH (adjusted OR [aOR] 1.72, 95% CI 1.05\u20132.81,\n p<\/jats:italic>\n \u2009=\u20090.030). Additionally, group 2 PH was associated with lower odds of PPM (aOR 1.53, 95% CI 1.26\u20131.85,\n p<\/jats:italic>\n \u2009<\u20090.001), longer LOS (5 vs. 3.69 days,\n p<\/jats:italic>\n \u2009<\u20090.001) and higher THC ($120,070 vs. $99,369,\n p<\/jats:italic>\n \u2009<\u20090.001). No differences were observed regarding odds of TPM use, cardiac arrest, stroke, AKI or all cause 30\u2010day readmissions between both groups.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Among patients with CHB, the presence of group 2 PH was associated with higher rates of fatal and non\u2010fatal adverse outcomes and lower utilization of PPMs compared to those without group 2 PH.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/ccd.70134","type":"journal-article","created":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T07:00:53Z","timestamp":1756796453000},"page":"2863-2869","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Exploring the Relationship between Group 2 Pulmonary Hypertension and Complete Heart Block: A United States Population Based Study"],"prefix":"10.1002","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-7645-1924","authenticated-orcid":false,"given":"Nadhem","family":"Abdallah","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Hennepin Healthcare Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdilahi","family":"Mohamoud","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Division of Cardiology, Hennepin Healthcare Minneapolis Minnesota USA"},{"name":"Minneapolis Heart Institute\u2010 Abbott Northwestern Hospital Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,2]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/2040622311420773"},{"issue":"10","key":"e_1_2_12_3_1","first-page":"e471","article-title":"Hypertension Art\u00e9rielle Pulmonaire De L'adulte [Pulmonary Arterial Hypertension in Adults]","volume":"67","author":"Bourlier D.","year":"2017","journal-title":"La Revue du Praticien"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/clc.23803"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.62.2.156"},{"key":"e_1_2_12_6_1","volume-title":"Clinical Classifications for Health Policy Research, Version 2: Hospital Inpatient Statistics","author":"Elixhauser A.","year":"1996"},{"key":"e_1_2_12_7_1","unstructured":"Healthcare Cost and Utilization Project. Introduction to the HCUP National Inpatient Sample (NIS). 2017 https:\/\/www.hcup-us.ahrq.gov\/db\/nation\/nis\/NIS_Introduction_2017.jsp."},{"issue":"3","key":"e_1_2_12_8_1","first-page":"47","article-title":"Characterizing Pulmonary Hypertension\u2010Related Hospitalization Costs Among Medicare Advantage or Commercially Insured Patients With Pulmonary Arterial Hypertension: A Retrospective Database Study","volume":"21","author":"Burke J. P.","year":"2015","journal-title":"The American Journal of Managed Care"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2014.07.079"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/clc.23803"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2012.06.024"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.616011"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.120.007505"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.616011)"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9149(00)01450-8"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eup383"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eur165"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2022.03.024"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/2045894018769874"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hlc.2021.10.002"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1964.tb53151.x"},{"issue":"3","key":"e_1_2_12_22_1","first-page":"47","article-title":"Characterizing Pulmonary Hypertension\u2010Related Hospitalization Costs Among Medicare Advantage or Commercially Insured Patients With Pulmonary Arterial Hypertension: A Retrospective Database Study","volume":"21","author":"Burke J. P.","year":"2015","journal-title":"American Journal of Managed Care"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.70134","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T19:05:11Z","timestamp":1762283111000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.70134"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,2]]},"references-count":21,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1002\/ccd.70134"],"URL":"https:\/\/doi.org\/10.1002\/ccd.70134","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"value":"1522-1946","type":"print"},{"value":"1522-726X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,2]]},"assertion":[{"value":"2025-05-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}