{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T07:30:17Z","timestamp":1771659017458,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T00:00:00Z","timestamp":1757030400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      First\u2010generation drug\u2010eluting stents (DES) with thick polymers may contribute to local vascular inflammation and late stent thrombosis. Thinner\u2010strut DES, particularly those with biodegradable polymers and ultrathin struts, aim to reduce this risk by minimizing flow disturbance and vascular injury. Nonetheless, the long\u2010term safety and efficacy of ultrathin biodegradable polymer sirolimus\u2010eluting stents (BP\u2010SES) compared to durable polymer everolimus\u2010eluting stents (DP\u2010EES) are still uncertain. Thus, we performed a meta\u2010analysis with the aim of comparing outcomes of these two stents. Inclusion criteria comprised randomized controlled trials (RCTs) that compared ultrathin\/thin BP\u2010SES and thin DP\u2010EES in patients undergoing percutaneous coronary interventions (PCI) and had long\u2010term follow\u2010up reports of at least 3 years. We excluded cohort studies, case reports, editorials, conference abstracts, and animal studies. Our primary outcomes were target lesion failure (TLF), cardiac death (CD), target\u2010vessel myocardial infarction (TV\u2010MI), and clinically indicated target lesion revascularization (CI\u2010TLR). We systematically searched PubMed, Cochrane CENTRAL, and Scopus. Cochrane's ROB 2.0 tool was used for assessing the quality of all included RCTs. RevMan software (5.4) was used to perform the meta\u2010analysis. Our analysis included 10 RCTs, totaling 16,216 patients, with 9108 in the BP\u2010SES group and 7108 in the DP\u2010EES group. TLF occurred in 905 patients (9.94%) in the BP\u2010SES group and 821 patients (11.55%) in the DP\u2010DES group, with no statistically significant differences between the groups (RR\u2009=\u20090.92, 95% CI\u2009=\u20090.85\u22121.01,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.08). Additionally, there were no significant differences in CD (RR\u2009=\u20091.00, 95% CI\u2009=\u20090.84\u22121.19,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20091.00), TV\u2010MI (RR\u2009=\u20090.91, 95% CI\u2009=\u20090.78\u22121.05,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.19), and CI\u2010TLR (RR\u2009=\u20090.88, 95% CI\u2009=\u20090.78\u22121.01,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.06) between the two groups. BP\u2010SES and DP\u2010EES showed comparable long\u2010term safety and efficacy in most PCI patients and lesion subsets. A significant reduction in TLF with BP\u2010SES was observed in STEMI, without increased thrombotic risk, while outcomes were consistent across other subgroups. Head\u2010to\u2010head analyses confirmed no major long\u2010term differences between Orsiro BP\u2010SES and Xience DP\u2010EES. In practice, either stent can be used with confidence, with BP\u2010SES favored in settings such as STEMI, where its potential advantages may offer additional clinical benefit.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.70147","type":"journal-article","created":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T07:31:11Z","timestamp":1757057471000},"page":"2975-2995","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Long\u2010Term Safety and Efficacy of Ultrathin Bioabsorbable\u2010Polymer Sirolimus\u2010Eluting Stents Versus Thin Durable\u2010Polymer Everolimus\u2010Eluting Stents in Patients Undergoing Percutaneous Coronary Intervention: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-5568-6037","authenticated-orcid":false,"given":"Merna M.","family":"Abouelenien","sequence":"first","affiliation":[{"name":"Faculty of Medicine Alexandria University Alexandria Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yousef","family":"Tanas","sequence":"additional","affiliation":[{"name":"Institute for Reconstructive Surgery, Houston Methodist Hospital Weill Cornell Medical College Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mennatullah E.","family":"Mekky","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Alexandria University Alexandria Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rewan","family":"Elgendy","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Alexandria University Alexandria Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdelrahman","family":"Zidan","sequence":"additional","affiliation":[{"name":"School of Medicine Emory University Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karam R.","family":"Motawea","sequence":"additional","affiliation":[{"name":"University Hospitals Cleveland Medical Center Case Western Reserve University Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehad191"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)31927-X"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.109.891192"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehm114"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8183.2007.00283.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.658237"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00019501-200409000-00003"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.32057"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1586\/14779072.6.10.1379"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.20692"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.03.042"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1607991"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.11.058"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab280"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2013.04.011"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-23-00409"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)02197-9"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_7_20_1","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions Version 6.5","author":"Higgins J. 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