{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T04:23:08Z","timestamp":1780546988796,"version":"3.54.1"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T00:00:00Z","timestamp":1757289600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Invasive coronary physiology including fractional flow reserve (FFR), instantaneous wave\u2010free ratio (iFR), and coronary flow reserve (CFR) are guideline\u2010endorsed tools to guide the management of coronary artery disease (CAD). Complex factors impact and confound these assessments, and discordance between modalities complicates clinical management. iEquate is a prospective observational trial that combines multi\u2010modality coronary physiology and optical coherence tomography (OCT) to identify the determinants of pressure\u2010wire derived myocardial ischemia and iFR\u2010FFR discordance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>All patients referred for invasive angiography who met the pre\u2010selection criteria were screened for inclusion and exclusion criteria. Patients underwent physiological assessment using iFR and FFR, and CFR was performed as indicated. OCT was performed on all suitable lesions. Data were collected on baseline demographics, angiographic results, OCT findings, coronary physiology, and procedural details. Multivariate analysis was performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 124 vessels were analyzed from 107 patients. The mean age was 67.6 (\u2009\u00b1\u200910.8) years, and 23 patients (21.5%) were female. Eighty (74.8%) presented with stable angina, and the most common vessel assessed was the left anterior descending artery (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200984, 67.7% of patients). The incidence of iFR\u2010FFR discordance was 20.7%, with 48% of these iFR+FFR\u2212. Calcific plaque was associated with discordance (OR 6.15 [95% CI [1.05\u221236.13];\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04), largely with a iFR+FFR\u2212 pattern (OR 7.62 [95% CI 0.38\u2212152.15];\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.184). Other morphological features were not predictive of FFR, iFR, or CFR findings. Mean CFR was significantly lower in the iFR+FFR\u2212 subgroup compared to FFR+iFR\u2212 (mean difference 1.4;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>iFR\u2010FFR discordance is common, and impaired vasodilatory capacity (assessed using CFR) may account for some of these cases. In this study, calcific plaque was associated with discordance, while other OCT\u2010derived plaque morphological characteristics were not associated with invasive coronary physiology findings. Cross\u2010sectional plaque eccentricity is associated with lower FFR values.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.70151","type":"journal-article","created":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T05:55:20Z","timestamp":1757397320000},"page":"3034-3046","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Impact of Epicardial plaQUe Composition and geomeTry on Coronary hEmodynamics and Flow in Patients With Coronary Artery Disease (iEquate)"],"prefix":"10.1002","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2892-7372","authenticated-orcid":false,"given":"Avedis","family":"Ekmejian","sequence":"first","affiliation":[{"name":"Royal North Shore Hospital St Leonards Australia"},{"name":"University of Sydney Northern Clinical School Sydney 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Clinical School Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravinay","family":"Bhindi","sequence":"additional","affiliation":[{"name":"Royal North Shore Hospital St Leonards Australia"},{"name":"University of Sydney Northern Clinical School Sydney 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