{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T22:35:36Z","timestamp":1780353336548,"version":"3.54.1"},"reference-count":46,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T00:00:00Z","timestamp":1757030400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Percutaneous coronary intervention (PCI) with drug\u2010eluting stents (DES) on ostial left circumflex (oLCx) is associated with a high rate of adverse events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study aims to compare drug\u2010coated balloons (DCB) and DES in the treatment of oLCx lesions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Consecutive patients undergoing DCB\u2010PCI of de novo oLCx lesions (isolated or in the context of a distal left main bifurcation) in eight international centers from 2018 to 2023 were retrospectively enrolled and compared with a historical cohort of patients who received PCI with DES.<\/jats:p>\n                    <jats:p>The primary endpoint was the 2\u2010year incidence of target lesion failure (TLF), a composite of target lesion revascularization (TLR), target vessel\u2010myocardial infarction and cardiac death, at time\u2010to\u2010first event analysis. Propensity\u2010score matching was adopted to adjust for clinical and angiographic confounders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 152 patients were included in the DCB group and 351 patients in the DES group. Patients in the DES group had more multivessel disease (94.6% vs. 82.7%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) but shorter lesions (18.0 [interquartile range, IQR: 15.0\u221228.0] vs. 25.5 [17.4\u221240.0]\u2009mm,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) than those in the DCB group. Fluoroscopy time (20.0 [IQR: 14.0\u221228.2] vs. 31.0 [21.0\u221245.5]\u2009min,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and amount of contrast used (150 [IQR: 120\u2212220] vs. 200 [140\u2212250]\u2009mL,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.006) were significantly lower in DCB\u2010PCI than DES\u2010PCI.\n                    <\/jats:p>\n                    <jats:p>The 2\u2010year rate of TLF was similar in the two groups (19.0% in the DCB group vs. 19.8% in the DES group, hazard ratio [HR]: 1.05, 95% confidence interval [CI] 0.64\u22121.75). This result remained consistent in the 126 pairs of patients obtained after propensity score matching.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In a multinational observational retrospective real\u2010world study including patients undergoing PCI on oLCx, no difference in TLF rate was detected between PCI with DCB and PCI with DES at a midterm follow\u2010up.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.70154","type":"journal-article","created":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T12:29:38Z","timestamp":1757075378000},"page":"2958-2968","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Drug\u2010Coated Balloons Versus Drug\u2010Eluting Stents for De Novo Ostial Left Circumflex Lesions: The International Multicenter DCB\u2010CIRCO 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