{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T19:10:22Z","timestamp":1762283422328,"version":"build-2065373602"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T00:00:00Z","timestamp":1757376000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Current guidelines recommend clopidogrel in patients with chronic coronary syndrome (CCS) undergoing percutaneous coronary intervention (PCI), yet the comparative benefits are unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The aim of this study was to evaluate the efficacy and safety of ticagrelor versus clopidogrel in patients with CCS undergoing PCI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We searched PubMed\/MEDLINE, EMBASE, CENTRAL databases from inception to February 15, 2025. We included parallel randomized controlled trials (RCTs) involving adults with CCS undergoing PCI, where the intervention group received ticagrelor as maintenance therapy and the control group received clopidogrel. Primary outcomes included all\u2010cause or cardiovascular mortality, myocardial infarction, quality of life, heart failure, stroke\/transient ischemic attack (TIA), revascularization, and adverse events. Study selection and data extraction were conducted independently. We determined the certainty of evidence using the GRADE approach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We included nine RCTs, with 3370 patients. Compared to clopidogrel, ticagrelor probably results in no important difference in cardiovascular mortality and hospital stay; may not have an important effect on stroke and\/or TIA; and may not have an important effect on all\u2010cause mortality, heart failure, and revascularization, but the evidence is very uncertain. Additionally, the evidence is very uncertain about the effect on myocardial infarction. Regarding safety outcomes, ticagrelor probably results in no important difference in major bleeding, minor bleeding, any bleeding, or dyspnea. However, it probably increases the risk of chest pain\/tightness (\u2009+\u20097.5 per 100; 95% CI: +1.4 to +21.7).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In patients with CCS undergoing PCI, ticagrelor probably has a similar efficacy and safety to clopidogrel in most cardiovascular outcomes. However, it probably increases the risk of chest pain\/tightness.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.70155","type":"journal-article","created":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T10:26:18Z","timestamp":1757413578000},"page":"3047-3058","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ticagrelor Versus Clopidogrel in Patients With Chronic Coronary Syndrome Undergoing Percutaneous Coronary Intervention: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4195-5335","authenticated-orcid":false,"given":"Johann Bill","family":"Pinedo\u2010Avila","sequence":"first","affiliation":[{"name":"Unidad de Cuidados Intensivos de Neurocirug\u00eda del Hospital Nacional Guillermo Almenara Irigoyen Lima Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9983-4133","authenticated-orcid":false,"given":"Jessica Lucia","family":"Valera\u2010Cabrera","sequence":"additional","affiliation":[{"name":"Universidad Peruana de Ciencias Aplicadas Lima Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Avalos\u2010Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Universidad San Mart\u00edn de Porres Lima Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4916-8416","authenticated-orcid":false,"given":"Sarita M.","family":"Fern\u00e1ndez\u2010Poma","sequence":"additional","affiliation":[{"name":"Universidad Nacional Federico Villarreal Lima Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5376-4122","authenticated-orcid":false,"given":"Carlos Enrique Mart\u00ednez","family":"Castro","sequence":"additional","affiliation":[{"name":"Universidad Privada Antenor Orrego (UPAO) Trujillo Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renzo G.","family":"Ca\u00f1ote","sequence":"additional","affiliation":[{"name":"Oftalmosalud Lima Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karina","family":"Chocce","sequence":"additional","affiliation":[{"name":"EviSalud\u2013Evidencias en Salud Lima Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8758-0463","authenticated-orcid":false,"given":"Alvaro","family":"Taype\u2010Rondan","sequence":"additional","affiliation":[{"name":"EviSalud\u2013Evidencias en Salud Lima Peru"},{"name":"Unidad de Investigaci\u00f3n para la Generaci\u00f3n y S\u00edntesis de Evidencia en Salud, Vicerrectorado de Investigaci\u00f3n Universidad San Ignacio de Loyola Lima Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3690-0014","authenticated-orcid":false,"given":"David R.","family":"Soriano\u2010Moreno","sequence":"additional","affiliation":[{"name":"Escuela de Medicina Universidad Peruana Uni\u00f3n Lima Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,9]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehae177"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(24)04310-9"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001052"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001038"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10040610"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mpmed.2022.04.008"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-21-00904"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32236-4"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpcardiol.2024.102635"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2024.0133"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcha.2024.101359"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d5928"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2021.03.026"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2019.10.014"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2023.12.011"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2024.04.015"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carrev.2021.06.129"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2024.03.027"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/00015385.2018.1429193"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/09537104.2020.1754381"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.034790"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40256-018-0302-3"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH16-12-0973"},{"key":"e_1_2_11_25_1","article-title":"Comparison of Ticagrelor and Clopidogrel in Elective Coronary Stenting: A Double Blind Randomized Clinical Trial","volume":"2023","author":"Parizi M. M.","year":"2023","journal-title":"Journal of Interventional Cardiology"},{"key":"e_1_2_11_26_1","unstructured":"\u201cA 30\u2010Day Randomized Evaluator\u2010Blind Controlled Multi\u2010Centre Parallel Group Phase III Study to Evaluate the Effect of a Low Maintenance Dose Ticagrelor Regimen Versus Standard Dose Clopidogrel [Internet] \u201d2025 https:\/\/trialsearch.who.int\/Trial2.aspx?TrialID=EUCTR2019%E2%80%90002226%E2%80%9079%E2%80%90SE."},{"key":"e_1_2_11_27_1","unstructured":"J.Kojuri \u201cA Single\u2010Center Randomized 6\u2010Month Non\u2010Inferiority Study to Compare the Safety and Efficacy of Ticagrelor Monotherapy Versus Dual Antiplatelet Therapy in Chronic Coronary Syndrome Patients Post Percutaneous Coronary Intervention (TICALONE) [Internet] \u201d2024 https:\/\/clinicaltrials.gov\/study\/NCT06509893."},{"key":"e_1_2_11_28_1","unstructured":"\u201cPharmacodynamic Effects of Low\u2010Dose Ticagrelor vs. Clopidogrel in Stable Patients Undergoing Elective Percutaneous Coronary Intervention Who Are at Risk of Peri\u2010PCI Myocardial Infarction Using a Precision Medicine Tool [Internet] \u201d University of Florida 2024 https:\/\/clinicaltrials.gov\/study\/NCT06228456."},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.1053867"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.70155","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T19:05:31Z","timestamp":1762283131000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.70155"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,9]]},"references-count":28,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1002\/ccd.70155"],"URL":"https:\/\/doi.org\/10.1002\/ccd.70155","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"type":"print","value":"1522-1946"},{"type":"electronic","value":"1522-726X"}],"subject":[],"published":{"date-parts":[[2025,9,9]]},"assertion":[{"value":"2025-05-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}