{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T06:49:34Z","timestamp":1794034174732,"version":"4.8.0"},"reference-count":38,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T00:00:00Z","timestamp":1759622400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T00:00:00Z","timestamp":1759622400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The CHA\u2082DS\u2082\u2010VASc score was originally developed to assess stroke risk in patients with atrial fibrillation (AF). Recently, it has been explored as a potential tool for predicting adverse cardiovascular outcomes after percutaneous coronary intervention (PCI). However, its effectiveness in this context remains underexplored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This review aims to evaluate the ability of the CHA\u2082DS\u2082\u2010VASc score to predict adverse cardiovascular outcomes in patients undergoing PCI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic review and meta\u2010analysis were conducted following PRISMA 2020 guidelines. Ten observational studies involving a total of 14,143 patients were included. The primary outcomes were ISR, AST, and MACE. Pooled odds ratios (ORs) or hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated using random\u2010effects models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Most included studies were observational with varying endpoints, follow\u2010up periods, and stent technologies, limiting causal inference, subgroup analyses, and introducing potential bias. The pooled analysis showed that higher CHA\u2082DS\u2082\u2010VASc scores were significantly associated with increased risks of ISR (OR: 2.21; 95% CI: 1.75\u20132.78), AST (OR: 1.99; 95% CI: 1.53\u20132.60), and MACE (HR: 1.44; 95% CI: 1.22\u20131.69).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The CHA\u2082DS\u2082\u2010VASc score shows strong predictive value for ISR, AST, and MACE after PCI. Its simplicity and ease of use make it a practical tool for bedside risk assessment in clinical settings. Future prospective, multicenter studies with patient\u2010level data are needed to validate the CHA\u2082DS\u2082\u2010VASc score in non\u2010AF populations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.70165","type":"journal-article","created":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T05:24:06Z","timestamp":1759728246000},"page":"3553-3563","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Role of CHA\u2082DS\u2082\u2010VASc Score in Predicting Clinical Complications Following Primary Percutaneous Coronary Intervention: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"106","author":[{"given":"Dwi","family":"Ariyanti","sequence":"first","affiliation":[{"name":"Subspecialist Study Program of Cardiology and Vascular Medicine, Faculty of Medicine Universitas Airlangga Surabaya Indonesia"},{"name":"Department of Cardiology and Vascular Medicine Dr. Soetomo General Academic Hospital Surabaya Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7711-8644","authenticated-orcid":false,"given":"Muhammad Farhan","family":"Hibatulloh","sequence":"additional","affiliation":[{"name":"Medical Professional Programme, Faculty of Medicine University of Jember Jember Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cinday Kinanti","family":"Pramusinta","sequence":"additional","affiliation":[{"name":"Medical Professional Programme, Faculty of Medicine University of Jember Jember Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Achmad Ilham","family":"Tohari","sequence":"additional","affiliation":[{"name":"Medical Professional Programme, Faculty of Medicine University of Jember Jember Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aqilla Sakanti","family":"Chandrarini","sequence":"additional","affiliation":[{"name":"Medical 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