{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T01:02:31Z","timestamp":1784682151367,"version":"3.55.0"},"reference-count":20,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T00:00:00Z","timestamp":1759708800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T00:00:00Z","timestamp":1759708800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Transcatheter edge\u2010to\u2010edge repair (TEER) improves outcomes in patients with heart failure and moderate\u2010to\u2010severe functional mitral regurgitation (FMR) who remain symptomatic despite the use of maximal doses of guideline\u2010directed medical therapy (GDMT). The SQ\u2010Kyrin\u2010M system is a novel TEER device designed for FMR treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This multicenter, prospective, single\u2010arm study (ClinicalTrials.gov number: NCT05988450) evaluates the safety and efficacy of the SQ\u2010Kyrin\u2010M system in severe symptomatic FMR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 125 eligible patients (mean age 65.5\u2009\u00b1\u20098.1 years) with heart failure and moderate\u2010to\u2010severe or severe FMR who remained symptomatic despite the use of maximal doses of GDMT were involved in the analysis. The primary endpoint was the composite rate of all\u2010cause mortality and heart failure hospitalization at 1 year post\u2010intervention. Independent assessments were conducted by an echocardiography core laboratory (ECL) and a clinical events committee (CEC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At 1 year, the primary endpoint rate was 16.0% (20\/125), and the composite major adverse event rate was 10.4%. Mitral regurgitation was reduced to \u2264\u20092+ in 94.2% of patients, with significant left ventricular reverse remodeling (LVEDV reduction: 33.8\u2009\u00b1\u200955.4\u2009mL,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Patient\u2010reported outcomes improved significantly, with Kansas City Cardiomyopathy Questionnaire (KCCQ) scores increasing by 15.9\u2009\u00b1\u200918.8 points (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and 6\u2010minute walk distance (6MWD) improving by 46.7\u2009\u00b1\u200990.7\u2009m (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). The proportion of patients in New York Heart Association (NYHA) class I\/II increased from 30.4% to 84.4% (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The SQ\u2010Kyrin\u2010M transcatheter mitral valve repair system bolsters the evidence supporting the safety and efficacy of TEER interventions for FMR patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.70230","type":"journal-article","created":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T05:21:51Z","timestamp":1759814511000},"page":"3574-3582","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["One\u2010Year Outcomes of Novel Transcatheter Edge\u2010to\u2010Edge Mitral Repair System in Patients With Functional Mitral Regurgitation"],"prefix":"10.1002","volume":"106","author":[{"given":"Kai","family":"Xu","sequence":"first","affiliation":[{"name":"General Hospital of Northern Theater Command Shenyang Liaoning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da","family":"Zhu","sequence":"additional","affiliation":[{"name":"Fuwai Yunnan Cardiovascular Hospital Kunming Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2895-3295","authenticated-orcid":false,"given":"Hong","family":"Jiang","sequence":"additional","affiliation":[{"name":"Renmin Hospital of Wuhan University Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Chen","sequence":"additional","affiliation":[{"name":"Renmin Hospital of Wuhan University Wuhan Hubei 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