{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T00:34:12Z","timestamp":1791592452494,"version":"4.3.4"},"reference-count":38,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T00:00:00Z","timestamp":1760313600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T00:00:00Z","timestamp":1760313600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>There is limited information on the use of drug\u2010coated balloons (DCBs) in chronic total occlusion (CTO) percutaneous coronary intervention (PCI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To assess the frequency and outcomes of DCB use in CTO PCI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study evaluated the frequency and outcomes of DCB use in a large, multicenter CTO PCI registry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed 12,146 patients who underwent 12,157 successful CTO PCIs at 59 centers from 2018 to 2025.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      DCBs were used in 454 patients (3.7%) with increasing frequency over time (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.020). A DCB\u2010only strategy was used in 48.4% of the patients and a hybrid strategy combining DCBs and drug\u2010eluting stents (DES) was used in 51.6% of patients. Patients treated with DCB (both strategies) had low prevalence of comorbidities. Compared with the DES cases, DCB only cases had favorable angiographic characteristics, lower mean J\u2010CTO (Japanese CTO) score (1.83\u2009\u00b1\u20091.03 vs. 2.27\u2009\u00b1\u20091.23;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), and similar technical success (96.3% vs. 97.3%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.640), and in\u2010hospital major adverse cardiac events (MACE). The hybrid and DCB\u2010only strategies had comparable technical success and in\u2010hospital MACE. During a median follow\u2010up of 323 (170\u2013429) days, DCB only cases had lower MACE than the other strategies (hazard ratio [HR] 0.41, 95% CI 0.17\u20130.96,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.040). After multivariable adjustment, the association remained significant (HR 0.39, 95% CI 0.16\u20130.92,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.032).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>DCBs are increasingly being used in CTO PCI. A DCB only strategy was used in less complex lesions and was associated with similar technical success and in\u2010hospital MACE compared with hybrid or DES strategies. A DCB only strategy was associated with lower long\u2010term MACE.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.70240","type":"journal-article","created":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T04:52:52Z","timestamp":1760417572000},"page":"3783-3795","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Drug\u2010Coated Balloons in Chronic Total Occlusion Percutaneous Coronary Intervention: Insights From the PROGRESS\u2010CTO Registry"],"prefix":"10.1002","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4432-4595","authenticated-orcid":false,"given":"Deniz","family":"Mutlu","sequence":"first","affiliation":[{"name":"Minneapolis Heart Institute and Minneapolis Heart Institute Foundation Abbott Northwestern Hospital Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2683-5255","authenticated-orcid":false,"given":"Athanasios","family":"Rempakos","sequence":"additional","affiliation":[{"name":"Corewell Health William Beaumont University Hospital Royal Oak Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6623-1715","authenticated-orcid":false,"given":"Dimitrios","family":"Strepkos","sequence":"additional","affiliation":[{"name":"Minneapolis Heart Institute and Minneapolis Heart Institute Foundation Abbott Northwestern Hospital Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0918-6759","authenticated-orcid":false,"given":"Pedro E. 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