{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T01:02:28Z","timestamp":1784682148138,"version":"3.55.0"},"reference-count":34,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:00:00Z","timestamp":1761004800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:00:00Z","timestamp":1761004800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Coronary artery disease (CAD) is a leading cause of death worldwide. Among acute coronary syndromes, non\u2010ST\u2010elevation myocardial infarction (NSTEMI) poses a higher long\u2010term risk than ST\u2010elevation myocardial infarction (STEMI). Eptifibatide, a glycoprotein IIb\/IIIa inhibitor, is used during percutaneous coronary intervention (PCI) to prevent clots, but its long\u2010term effects in NSTEMI patients remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study assesses the impact of Eptifibatide on major adverse cardiac events (MACE) and survival in NSTEMI patients undergoing PCI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective cohort study of NSTEMI patients treated between 2015 and 2022 at Tehran Heart Center. Patients were grouped based on whether they received Eptifibatide. MACE outcomes were tracked during hospitalization and 1 year later. Statistical adjustments were made for baseline differences.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 5309 patients, 12% received Eptifibatide. There were no significant differences between groups in MACE (17.2% vs. 15.6%) or survival (HR 0.97,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.901).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Eptifibatide showed no significant effect on MACE or survival in NSTEMI patients undergoing PCI. Further research is needed to explore its role in high\u2010risk subgroups.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.70242","type":"journal-article","created":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T05:26:17Z","timestamp":1761110777000},"page":"3928-3938","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Can Eptifibatide Rewrite the NSTEMI Story? (Eptifibatide vs. Standard Care for NSTEMI: A 5\u2010Year Analysis of Major Adverse Cardiovascular Events)"],"prefix":"10.1002","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-4511-7659","authenticated-orcid":false,"given":"Parvin","family":"Kalhor","sequence":"first","affiliation":[{"name":"Tehran Heart Center Cardiovascular Disease Research Institute Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pargol","family":"Nowrouzi","sequence":"additional","affiliation":[{"name":"Tehran Heart Center Cardiovascular Disease Research Institute Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parichehr","family":"Ghahari","sequence":"additional","affiliation":[{"name":"Doctor of Medicine Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi","family":"Mehrani","sequence":"additional","affiliation":[{"name":"Tehran Heart Center Cardiovascular Disease Research Institute Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,21]]},"reference":[{"issue":"48","key":"e_1_2_9_2_1","first-page":"4738","article-title":"2023 ESC Guidelines for the Management of Acute Coronary Syndromes in Patients Presenting Without Persistent ST\u2010Segment Elevation","volume":"44","author":"Roffi M.","year":"2023","journal-title":"European Heart Journal"},{"issue":"5","key":"e_1_2_9_3_1","first-page":"255","article-title":"Epidemiology and Management of Coronary Artery Disease in Older Adults","volume":"20","author":"Aronow W. 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H.","year":"2023","journal-title":"American Heart Journal"},{"issue":"21","key":"e_1_2_9_10_1","first-page":"1912","article-title":"Microvascular Obstruction After PCI: Insights into Mechanisms and Strategies for Improvement","volume":"81","author":"Hochman J. S.","year":"2023","journal-title":"Journal of the American College of Cardiology"},{"issue":"4","key":"e_1_2_9_11_1","first-page":"334","article-title":"Strategies to Improve Myocardial Perfusion After PCI","volume":"9","author":"Brouwer M. A.","year":"2023","journal-title":"European Heart Journal\u2010Cardiovascular Pharmacotherapy"},{"issue":"2","key":"e_1_2_9_12_1","first-page":"126","article-title":"Advances in Antiplatelet Therapy for Acute Coronary Syndrome","volume":"9","author":"Norris J. M.","year":"2024","journal-title":"JAMA Cardiology"},{"issue":"19","key":"e_1_2_9_13_1","first-page":"1637","article-title":"Antiplatelet Therapy in Acute Coronary Syndromes: Current Guidelines and Emerging Therapies","volume":"147","author":"Cohen M.","year":"2023","journal-title":"Circulation"},{"key":"e_1_2_9_14_1","first-page":"104","article-title":"Eptifibatide in Acute Coronary Syndromes: An Updated Review","volume":"186","author":"Stone G. W.","year":"2023","journal-title":"American Journal of Cardiology"},{"issue":"1","key":"e_1_2_9_15_1","first-page":"45","article-title":"The Role of GPIIb\/IIIa Inhibitors in the Current Era of PCI","volume":"36","author":"Serruys P. W.","year":"2023","journal-title":"Journal of Interventional Cardiology"},{"issue":"28","key":"e_1_2_9_16_1","first-page":"2498","article-title":"The Role of GPIIb\/IIIa Inhibitors in NSTEMI: Current Evidence and Future Perspectives","volume":"44","author":"Kotecha D.","year":"2023","journal-title":"European Heart Journal"},{"issue":"2","key":"e_1_2_9_17_1","first-page":"101","article-title":"Safety and Efficacy of Eptifibatide Compared With Other GPIIb\/IIIa Inhibitors in PCI","volume":"36","author":"Grines C. L.","year":"2023","journal-title":"Journal of Interventional Cardiology"},{"issue":"1","key":"e_1_2_9_18_1","article-title":"Cost\u2010Effectiveness of Antiplatelet Therapies in NSTEMI","volume":"13","author":"Bangalore S.","year":"2024","journal-title":"Journal of the American Heart Association"},{"issue":"1","key":"e_1_2_9_19_1","first-page":"34","article-title":"Evaluation of Eptifibatide in NSTEMI Patients: A Multicenter Study","volume":"149","author":"Muller R.","year":"2024","journal-title":"Circulation"},{"issue":"2","key":"e_1_2_9_20_1","first-page":"112","article-title":"Healthcare Costs Associated With NSTEMI: A Detailed Analysis","volume":"29","author":"Farrell M.","year":"2023","journal-title":"American Journal of Managed Care"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12072459"},{"key":"e_1_2_9_22_1","first-page":"64","article-title":"Eptifibatide and Baseline Characteristics in NSTEMI: A Contemporary Review","volume":"239","author":"Garcia D.","year":"2024","journal-title":"American Heart Journal"},{"key":"e_1_2_9_23_1","first-page":"55","article-title":"Eptifibatide vs. Alternative Therapies in NSTEMI: A Comparative Study","volume":"238","author":"Wu A.","year":"2024","journal-title":"American Heart Journal"},{"issue":"6","key":"e_1_2_9_24_1","first-page":"345","article-title":"Pharmacogenomics of Antiplatelet Therapy in Cardiovascular Disease","volume":"20","author":"Lee C. 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D.","year":"2023","journal-title":"American Journal of Cardiology"},{"issue":"1","key":"e_1_2_9_29_1","first-page":"33","article-title":"Evaluating Healthcare Costs and Long\u2010Term Outcomes in NSTEMI Patients","volume":"14","author":"Davies A.","year":"2024","journal-title":"Health Economics Review"},{"key":"e_1_2_9_30_1","first-page":"101","article-title":"The Impact of Antiplatelet Therapies on Healthcare Systems: A Review","volume":"41","author":"Johnson H.","year":"2024","journal-title":"Journal of Health Economics"},{"issue":"2","key":"e_1_2_9_31_1","first-page":"157","article-title":"Investigating Eptifibatide's Role in Diverse Clinical Settings","volume":"46","author":"Martin S.","year":"2023","journal-title":"Clinical Cardiology"},{"issue":"1","key":"e_1_2_9_32_1","first-page":"45","article-title":"Eptifibatide in Combination Therapies: Evidence and Future Directions","volume":"38","author":"Nguyen T. T.","year":"2024","journal-title":"Cardiovascular Drugs and Therapy"},{"issue":"4","key":"e_1_2_9_33_1","first-page":"321","article-title":"Assessing Long\u2010Term Outcomes and Quality of Life With Eptifibatide","volume":"38","author":"Harris K.","year":"2023","journal-title":"Journal of Cardiovascular Nursing"},{"issue":"6","key":"e_1_2_9_34_1","first-page":"917","article-title":"Evaluating the Clinical Value of Eptifibatide in NSTEMI: A Summary of Recent Findings","volume":"110","author":"Taylor W.","year":"2024","journal-title":"Heart"},{"issue":"1","key":"e_1_2_9_35_1","first-page":"72","article-title":"Future Research Directions for Eptifibatide in NSTEMI Treatment","volume":"22","author":"Brown L.","year":"2024","journal-title":"Journal of Cardiovascular Medicine"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.70242","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccd.70242","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.70242","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:21:46Z","timestamp":1784679706000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.70242"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,21]]},"references-count":34,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1002\/ccd.70242"],"URL":"https:\/\/doi.org\/10.1002\/ccd.70242","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"value":"1522-1946","type":"print"},{"value":"1522-726X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,21]]},"assertion":[{"value":"2025-06-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}