{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T18:16:30Z","timestamp":1785176190286,"version":"3.55.0"},"reference-count":13,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T00:00:00Z","timestamp":1760400000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T00:00:00Z","timestamp":1760400000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Vessel fractional flow reserve (vFFR) is an angiogram\u2010based technique validated in early studies; however, data on its real\u2010time diagnostic performance and integration into routine workflow remain limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The VERMONT study evaluated the diagnostic accuracy and time efficiency of real\u2010time vFFR versus conventional wire\u2010based FFR in detecting functionally significant coronary lesions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a prospective, single\u2010center, blinded study in which vFFR was measured during coronary angiography and compared with simultaneous wire\u2010based FFR. A wire\u2010based FFR of \u2264\u20090.80 defined a physiologically significant lesion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In 209 patients with 225 intermediate lesions, only 20 (8.9%) of lesions were excluded from vFFR analysis. vFFR demonstrated an AUC of 0.92 (95% CI, 0.89\u22120.96) for detecting lesions with FFR\u2009\u2264\u20090.80, achieving 90% sensitivity, 79% specificity, a negative predictive value of 93%, and a positive predictive value of 74%. Interobserver agreement was excellent (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.97,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Real\u2010time vFFR computation was on average 13.9\u2009min faster than wire\u2010based FFR (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Real\u2010time vFFR demonstrated excellent diagnostic performance with high sensitivity and NPV for identifying functionally significant intermediate lesions, supporting its use as a reliable screening tool. Importantly, this was achieved with a low exclusion rate, rapid computation time, and minimal interobserver variability, underscoring its practicality in routine clinical practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.70250","type":"journal-article","created":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T13:13:13Z","timestamp":1760447593000},"page":"3757-3765","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["VERMONT: Vessel Fractional Flow Reserve (vFFR) Assessment of Stenosis Severity: A Prospective Study"],"prefix":"10.1002","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6701-9094","authenticated-orcid":false,"given":"Daniel","family":"Akrawi","sequence":"first","affiliation":[{"name":"Department of Cardiology Campbelltown Hospital Sydney New South Wales Australia"},{"name":"Department of Cardiology Liverpool Hospital Sydney New South Wales Australia"},{"name":"School of Medicine Western Sydney University Campbelltown New South Wales Australia"},{"name":"School of Medicine University of New South Wales Liverpool New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishna","family":"Kadappu","sequence":"additional","affiliation":[{"name":"Department of Cardiology Campbelltown Hospital Sydney New South Wales Australia"},{"name":"School of Medicine Western Sydney University Campbelltown New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Cardiology Liverpool Hospital Sydney New South Wales Australia"},{"name":"School of Medicine University of New South Wales Liverpool New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamer Yousef Naguib","family":"Badie","sequence":"additional","affiliation":[{"name":"Department of Cardiology Campbelltown Hospital Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Gibbs","sequence":"additional","affiliation":[{"name":"Department of Cardiology Campbelltown Hospital Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hashim","family":"Kachwalla","sequence":"additional","affiliation":[{"name":"Department of Cardiology Campbelltown Hospital Sydney New South Wales Australia"},{"name":"School of Medicine Western Sydney University Campbelltown New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phong T. D.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Campbelltown Hospital Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul","family":"Kurup","sequence":"additional","affiliation":[{"name":"Department of Cardiology Campbelltown Hospital Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Upul","family":"Premawardhana","sequence":"additional","affiliation":[{"name":"Department of Cardiology Campbelltown Hospital Sydney New South Wales Australia"},{"name":"School of Medicine Western Sydney University Campbelltown New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sidney","family":"Lo","sequence":"additional","affiliation":[{"name":"Department of Cardiology Liverpool Hospital Sydney New South Wales Australia"},{"name":"School of Medicine University of New South Wales Liverpool New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justyn","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Campbelltown Hospital Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Tran","sequence":"additional","affiliation":[{"name":"Department of Cardiology Campbelltown Hospital Sydney New South Wales Australia"},{"name":"School of Medicine Sydney University Camperdown New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kavie","family":"Soosapilla","sequence":"additional","affiliation":[{"name":"Department of Cardiology Campbelltown Hospital Sydney New South Wales Australia"},{"name":"School of Medicine Western Sydney University Campbelltown New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiden","family":"O'Loughlin","sequence":"additional","affiliation":[{"name":"Department of 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