{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T07:51:18Z","timestamp":1767772278298,"version":"3.48.0"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:00:00Z","timestamp":1761609600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The role of intra\u2010aortic balloon pump (IABP) in acute coronary syndrome (ACS) patients undergoing percutaneous coronary intervention (PCI) without cardiogenic shock remains controversial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To assess the association between IABP use and in\u2010hospital mortality in this population and to identify high\u2010risk subgroups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This multicenter retrospective study analyzed data from the CCC\u2010ACS Project. Propensity score matching (PSM) and multivariable logistic regression were performed to adjust for confounders. Subgroup analyses identified patients groups at greater risk. A supplementary meta\u2010analysis was conducted to reflect existing uncertainty in the broader literature.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 32,863 ACS patients, 1,127 (3.4%) received IABP. In the propensity\u2010matched cohort, IABP use was associated with higher in\u2010hospital mortality (adjusted OR: 2.56, 95% CI: 1.30\u20135.04,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.006). The risk was more pronounced in patients with ST\u2010segment elevation myocardial infarction, heart failure, reduced left ventricular ejection fraction, and renal impairment. The meta\u2010analysis of 10 studies showed no significant association between IABP use and mortality (RR\u2009=\u20091.06, 95% CI: 0.79\u20131.42,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.70).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>IABP use in ACS patients without cardiogenic shock was associated with increased in\u2010hospital mortality, particularly among high\u2010risk subgroups. Careful patient selection is warranted, and further research is needed to refine its clinical indications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.70257","type":"journal-article","created":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T05:46:44Z","timestamp":1761716804000},"page":"23-33","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Intra\u2010Aortic Balloon Pump Use in Acute Coronary Syndrome Without Cardiogenic Shock: Association With Mortality in the CCC\u2010ACS Cohort"],"prefix":"10.1002","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-0567-7883","authenticated-orcid":false,"given":"Chu","family":"Fan","sequence":"first","affiliation":[{"name":"Department of Cardiology, Beijing AnZhen Hospital, Capital Medical University National Clinical Research Center for Cardiovascular Diseases Beijing 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