{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T01:02:29Z","timestamp":1784682149833,"version":"3.55.0"},"reference-count":27,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T00:00:00Z","timestamp":1760313600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T00:00:00Z","timestamp":1760313600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>Fractional flow reserve (FFR) is a validated tool for assessing epicardial coronary stenosis. In myocardial infarction (MI), microvascular dysfunction may impair hyperemic flow, potentially affecting the interpretation of FFR measurement. The FLOVITA Study (NCT04818918) aimed to assess the impact of prior myocardial necrosis on absolute coronary blood flow and resistance using pressure wire\u2010based continuous thermodilution.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This prospective pilot study included 40 patients undergoing coronary physiological assessment of the left anterior descending (LAD) artery between May 2021 and February 2024. Patients were stratified into two groups: recent anterior ST\u2010elevation MI (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200923) and controls without history or imaging evidence of MI (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200917). Absolute coronary blood flow and microvascular resistance were measured using pressure wire\u2010derived continuous thermodilution. This novel technique allows direct, operator\u2010independent quantification of coronary flow and microvascular resistance, offering high reproducibility. Multivariable linear regression identified factors associated with absolute coronary blood flow.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      LAD absolute blood flow was significantly lower in the MI group compared to controls (0.169\u2009\u00b1\u20090.005 vs. 0.215\u2009\u00b1\u20090.05\u2009L\/min;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.006), despite similar FFR values and macrovascular resistance. Infarct size and microvascular resistance were independently associated with reduced flow. Each 10% increase in infarct size was associated with a 0.01\u2009L\/min reduction in LAD flow (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.026), while a 100\u2009WU increase in microvascular resistance corresponded to a 0.02\u2009L\/min decrease (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The FLOVITA study is a proof\u2010of\u2010concept analysis suggesting that MI significantly reduces coronary blood flow through increased microvascular resistance. These findings underscore the importance of accounting for microvascular dysfunction when interpreting post\u2010MI coronary physiology.<\/jats:p>\n                    <jats:p>\n                      Registered with\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/ClinicalTrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      under the identifier NCT04818918.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.70268","type":"journal-article","created":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T19:25:49Z","timestamp":1760383549000},"page":"3588-3596","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Absolute Coronary Flow Reduction Mediated by Microvascular Resistance in Myocardial Infarction: The FLOVITA Study"],"prefix":"10.1002","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9163-8573","authenticated-orcid":false,"given":"Benoit","family":"Guillon","sequence":"first","affiliation":[{"name":"Department of Cardiology University Hospital Besan\u00e7on Besan\u00e7on France"},{"name":"SINERGIES Universit\u00e9 de Franche\u2010Comt\u00e9 Besan\u00e7on France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthieu","family":"Besutti","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Hospital Besan\u00e7on Besan\u00e7on France"},{"name":"SINERGIES Universit\u00e9 de Franche\u2010Comt\u00e9 Besan\u00e7on France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucie","family":"Revel","sequence":"additional","affiliation":[{"name":"Department of Radiology University Hospital Besan\u00e7on Besan\u00e7on France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010France","family":"Seronde","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Hospital Besan\u00e7on Besan\u00e7on France"},{"name":"SINERGIES Universit\u00e9 de Franche\u2010Comt\u00e9 Besan\u00e7on France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Meneveau","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Hospital Besan\u00e7on Besan\u00e7on France"},{"name":"SINERGIES Universit\u00e9 de Franche\u2010Comt\u00e9 Besan\u00e7on France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8358-515X","authenticated-orcid":false,"given":"Romain","family":"Chopard","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Hospital Besan\u00e7on Besan\u00e7on France"},{"name":"SINERGIES Universit\u00e9 de Franche\u2010Comt\u00e9 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