{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T04:49:43Z","timestamp":1767761383876,"version":"3.48.0"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T00:00:00Z","timestamp":1762819200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Several studies have reported the effectiveness of drug\u2010coated balloon (DCB) for femoropopliteal (FP) chronic total occlusion (CTO).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The EAGLE study aimed to investigate the real\u2010world clinical outcomes of DCB for FP CTO lesions at 3 years. Four risk factors for 1\u2010year restenosis were considered: hemodialysis, chronic limb\u2010threatening ischemia, restenosis lesion, and no dual antiplatelet therapy use.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective multicenter registry analyzed 359 limbs of 318 patients who underwent endovascular therapy with DCB for FP CTO between July 2017 and February 2021. The primary outcome was 3\u2010year primary patency. Secondary outcomes were 3\u2010year rates of freedom from: clinically driven target lesion revascularization (CD\u2010TLR); re\u2010occlusion; acute limb ischemia (ALI). Three\u2010year clinical outcomes, based on four 1\u2010year restenosis risk factors, were investigated using Cox proportional hazards regression models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The 3\u2010year rate of primary patency was 47.9% (95% confidence interval: 42.2%\u221254.4%), whereas the corresponding rates of freedom from CD\u2010TLR, re\u2010occlusion, and ALI were 61.9% (56.4%\u221268.0%), 77.5% (72.3%\u221283.1%), and 96.4% (94.3%\u221298.5%), respectively. The bailout stent rate was 8.9%. Risk factor accumulation was associated with a lower rate of 3\u2010year freedom from restenosis. Primary patency rates were 47.9% overall, with subgroup results of 65.2% (no risk factors), 47.1% (one risk factor), and 29.8% (two or more).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Outcomes of DCB for FP CTOs of patients without restenosis factors at 1 year were acceptable, but 3\u2010year patency was low in patients with multiple risk factors. Freedom from CD\u2010TLR, re\u2010occlusion, and ALI outcomes were acceptable.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.70332","type":"journal-article","created":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T05:39:47Z","timestamp":1762925987000},"page":"248-257","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Three Year Clinical Outcomes of Drug\u2010Coated Balloons in Patients With Femoropopliteal Chronic Total Occlusion: Results From the Multicenter EAGLE Study"],"prefix":"10.1002","volume":"107","author":[{"given":"Naoki","family":"Hayakawa","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine Asahi General Hospital Asahi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuyoshi","family":"Takahara","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine The University of Osaka Graduate School of Medicine 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