{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:52:37Z","timestamp":1773103957112,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T00:00:00Z","timestamp":1763078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Microvascular injury (MVI) increases the risk of heart failure and mortality in patients with ST\u2010elevation myocardial infarction (STEMI). Therefore, it is important to detect these patients at an early stage for additional (experimental) therapies to improve outcomes. Currently, there are no methods to diagnose MVI in STEMI patients before reperfusion. The objective of this study was to assess the invasively measured infarct\u2010related absolute myocardial resistance (\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sub>infarction<\/jats:sub>\n                      ) to predict MVI before reperfusion. Cardiac magnetic resonance imaging (CMR) characterizes MVI, in the forms of microvascular obstruction (MVO) and intramyocardial hemorrhage (IMH) with IMH being at the \u201cextreme\u201d end of the injury spectrum.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this substudy of the EURO\u2010ICE trial, R\n                      <jats:sub>\n                        <jats:italic>infarction<\/jats:italic>\n                      <\/jats:sub>\n                      was calculated as the change in distal coronary pressure during saline infusion in the occluded culprit artery, divided by the flow rate of the infused saline. The primary endpoint was to assess the diagnostic performance of R\n                      <jats:sub>\n                        <jats:italic>infarction<\/jats:italic>\n                      <\/jats:sub>\n                      to predict MVO on CMR performed at 2\u20137 days. The secondary endpoint was a composite of all\u2010cause mortality or hospitalization for heart failure up to 5 years.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 82 patients were included. The area under the Receiver\u2010Operating Characteristic curve of\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sub>infarction<\/jats:sub>\n                      to predict MVO and IMH was 0.84 and 0.78, respectively. The optimal cut\u2010off value for both MVO and IMH was 1000 Wood units (WU). The composite endpoint of all\u2010cause mortality or hospitalization for heart failure occurred in 15.6% and 2.3% in the\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sub>infarction<\/jats:sub>\n                      \u2009\u2265\u20091000 WU and\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sub>infarction<\/jats:sub>\n                      \u2009&lt;\u20091000 WU groups, respectively (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.06).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sub>infarction<\/jats:sub>\n                      is able to predict MVI in STEMI before reperfusion and may serve as a tool in future trials to select patients that might benefit most from experimental therapies.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.70338","type":"journal-article","created":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T11:24:27Z","timestamp":1763119467000},"page":"279-287","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Infarct\u2010Related Myocardial Resistance Before Reperfusion in Patients With Acute Myocardial Infarction to Predict Microvascular Injury and Clinical Outcomes"],"prefix":"10.1002","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9346-1265","authenticated-orcid":false,"given":"Konrad A. J.","family":"van Beek","sequence":"first","affiliation":[{"name":"Department of Cardiology Catharina Hospital Eindhoven the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarosh","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Cardiology Essex Cardiothoracic Centre Basildon UK"},{"name":"Anglia Ruskin School of medicine and MTRC Anglia Ruskin University, Chelmsford Essex UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haroun","family":"Butt","sequence":"additional","affiliation":[{"name":"Department of Cardiology Essex Cardiothoracic Centre Basildon UK"},{"name":"Anglia Ruskin School of medicine and MTRC Anglia Ruskin University, Chelmsford Essex UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6506-7108","authenticated-orcid":false,"given":"Jesse P. A.","family":"Demandt","sequence":"additional","affiliation":[{"name":"Department of Cardiology Catharina Hospital Eindhoven the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3585-0999","authenticated-orcid":false,"given":"Rob","family":"Eerdekens","sequence":"additional","affiliation":[{"name":"Department of Cardiology Catharina Hospital Eindhoven the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daimy M. M.","family":"Dillen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Catharina Hospital Eindhoven the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8695-7994","authenticated-orcid":false,"given":"Thomas R.","family":"Keeble","sequence":"additional","affiliation":[{"name":"Department of Cardiology Essex Cardiothoracic Centre Basildon UK"},{"name":"Anglia Ruskin School of medicine and MTRC Anglia Ruskin University, Chelmsford Essex UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Good","sequence":"additional","affiliation":[{"name":"School of Cardiovascular and Metabolic Health University of Glasgow and Golden Jubilee National Hospital Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colin","family":"Berry","sequence":"additional","affiliation":[{"name":"School of Cardiovascular and Metabolic Health University of Glasgow and Golden Jubilee National Hospital Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Engstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Cardiology Rigshospitalet, University of Copenhagen  Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jasmine M.","family":"Madsen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Rigshospitalet, University of Copenhagen  Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keith G.","family":"Oldroyd","sequence":"additional","affiliation":[{"name":"School of Cardiovascular and Metabolic Health University of Glasgow and Golden Jubilee National Hospital Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Branko","family":"Beleslin","sequence":"additional","affiliation":[{"name":"Department of Cardiology Clinical Center of Serbia Belgrade Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernard","family":"de Bruyne","sequence":"additional","affiliation":[{"name":"Cardiovascular Center Aalst OLV\u2010Clinic Aalst Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Corradetti","sequence":"additional","affiliation":[{"name":"Cardiovascular Center Aalst OLV\u2010Clinic Aalst Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ole","family":"Fr\u00f6bert","sequence":"additional","affiliation":[{"name":"Department of Cardiology, \u00d6rebro University Faculty of Health \u00d6rebro Sweden"},{"name":"Department of Biomedicine Aarhus Universitet Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth","family":"Mangion","sequence":"additional","affiliation":[{"name":"School of Cardiovascular and Metabolic Health University of Glasgow and Golden Jubilee National Hospital Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koen","family":"Teeuwen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Catharina Hospital Eindhoven the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcel","family":"van't Veer","sequence":"additional","affiliation":[{"name":"Department of Cardiology Catharina Hospital Eindhoven the Netherlands"},{"name":"Department of Biomedical Engineering Technical University Eindhoven Eindhoven the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nico H. 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