{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T16:56:55Z","timestamp":1793725015574,"version":"4.6.1"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T00:00:00Z","timestamp":1764460800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T00:00:00Z","timestamp":1764460800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Frailty is associated with poorer short\u2010term outcomes after transcatheter aortic valve implantation (TAVI), and national guidelines recommend an assessment of frailty as part of the decision\u2010making process. However, multiple frailty indices are currently used in clinical practice, and it is unclear which has the best discrimination in TAVI patients and whether this extends into the long term.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>We therefore aimed to compare three commonly used frailty indices in a large TAVI cohort and examine their ability to predict 5\u2010year outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The study population included 1059 patients from a high\u2010volume UK TAVI center from 2007 to 2019. Data were collected prospectively using a data set recommended by the British Cardiovascular Intervention Society (BCIS). Frailty was assessed using the Rockwood Clinical Frailty Scale (CFS), Karnofsky Performance Index, and the Katz Index of Activities of Daily Living. Follow\u2010up data were obtained from the NHS Spine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      One, three, and five\u2010year survival was 86.5%, 66.7%, and 44.9%, respectively. In univariate analysis, all three frailty indices were predictive of 5\u2010year survival (Rockwood CFS HR: 1.34 [\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01]; Katz HR: 1.23 [\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01]; Karnofsky HR: 1.21 [\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01]). Three separate multivariable Cox regression models were constructed for each frailty index. In each model, the frailty indices remained predictive of 5\u2010year survival. ROC curve comparison, however, demonstrated the Rockwood CFS model as the best discriminator of 5\u2010year survival (Rockwood CFS model: AUC\u2009=\u20090.59, Karnofsky model: AUC\u2009=\u20090.55, Katz model: AUC\u2009=\u20090.55,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04); pairwise analysis further confirmed the superiority of the Rockwood CFS model.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our study confirms that frailty is an important predictor of long\u2010term outcome following TAVI. Our study suggests that of the three most commonly used scoring systems, the most useful discriminator of long\u2010term outcome is the Rockwood CFS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.70380","type":"journal-article","created":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T04:14:13Z","timestamp":1764562453000},"page":"600-607","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Superiority of the Rockwood Clinical Frailty Scale for Assessing Long\u2010Term Outcome in Patients Undergoing Transcatheter Aortic Valve Implantation"],"prefix":"10.1002","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-8703-851X","authenticated-orcid":false,"given":"Timothy J.","family":"Bagnall","sequence":"first","affiliation":[{"name":"Sussex Cardiac Centre Royal Sussex County Hospital Brighton UK"},{"name":"Brighton and Sussex Medical School Brighton and Hove 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County Hospital Brighton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Parker","sequence":"additional","affiliation":[{"name":"Sussex Cardiac Centre Royal Sussex County Hospital Brighton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Parish","sequence":"additional","affiliation":[{"name":"Sussex Cardiac Centre Royal Sussex County Hospital Brighton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Michail","sequence":"additional","affiliation":[{"name":"Sussex Cardiac Centre Royal Sussex County Hospital Brighton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Cockburn","sequence":"additional","affiliation":[{"name":"Sussex Cardiac Centre Royal Sussex County Hospital Brighton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Hildick\u2010Smith","sequence":"additional","affiliation":[{"name":"Sussex Cardiac Centre Royal Sussex County Hospital Brighton UK"},{"name":"Brighton and Sussex Medical School Brighton and Hove UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"Broyd","sequence":"additional","affiliation":[{"name":"Sussex Cardiac Centre Royal Sussex County Hospital Brighton UK"},{"name":"Brighton and Sussex Medical School Brighton and Hove UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,30]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1008232"},{"key":"e_1_2_9_3_1","first-page":"520","article-title":"Transcatheter Aortic Valve Implantation: A Canadian Cardiovascular Society Position Statement","volume":"28","author":"John J.","year":"2012","journal-title":"Canadian Journal of 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